Try our beta test site
IMPORTANT: Listing of a study on this site does not reflect endorsement by the National Institutes of Health. Talk with a trusted healthcare professional before volunteering for a study. Read more...

Effect of Beta-Alanine on Heart Rate Response

This study has been completed.
Information provided by (Responsible Party):
Abbie Smith-Ryan, PhD, University of North Carolina, Chapel Hill Identifier:
First received: December 5, 2012
Last updated: April 29, 2013
Last verified: April 2013
Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation. The physical working capacity test has been used to show significant increases in physical working capacities following supplementation. The physical working capacity tests were originally developed by Moritani et al. 1981 and Devries et al. 1982 to measure the point of onset of muscular fatigue. It is hypothesized that beta-alanine will increase physical working capacity at heart rate threshold, thereby signifying a delay in fatigue.

Condition Intervention
Dietary Supplement: Placebo
Dietary Supplement: Beta-alanine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Double Blind (Participant, Investigator)
Official Title: The Effect of 28 Days of Beta-alanine Supplementation on the Physical Working Capacity at Heart Rate Threshold (PWCHRT)

Resource links provided by NLM:

Further study details as provided by University of North Carolina, Chapel Hill:

Primary Outcome Measures:
  • Physical working capacity at heart rate threshold [ Time Frame: 0 to 4 weeks ]

Enrollment: 35
Study Start Date: January 2013
Study Completion Date: April 2013
Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Placebo
Dietary Supplement: Placebo
Experimental: Beta-Alanine
Dietary Supplement: Beta-alanine

Detailed Description:
An equal number of men and women will be recruited [Men, n=20 (10 placebo [PL]; 10 beta-alanine (Active)]; [Women,n=20 (10 PL; 10 Active)]. Men and women will be randomly assigned to respective groups to allow for equal numbers in supplement and placebo groups.

Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Between the ages of 18-35 years old
  • Be recreationally active (defined as accumulating 1-5 hours of moderate intensity

Exclusion Criteria

  • Any health risks or indicators that would prevent them from participating in physical activity, as determined by a health history questionnaire
  • Must not have taken performance enhancing supplements containing beta-alanine or creatine during the last 3 months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01745016

United States, North Carolina
UNC Exercise and Sport Science
Chapel Hill, North Carolina, United States, 27599
Sponsors and Collaborators
University of North Carolina, Chapel Hill
  More Information

Responsible Party: Abbie Smith-Ryan, PhD, Assistant Professor, University of North Carolina, Chapel Hill Identifier: NCT01745016     History of Changes
Other Study ID Numbers: 12-1787
Study First Received: December 5, 2012
Last Updated: April 29, 2013

Keywords provided by University of North Carolina, Chapel Hill:
dietary supplement

Additional relevant MeSH terms:
Signs and Symptoms processed this record on April 28, 2017