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ClinicalTrials.gov Identifier: NCT01745016
: December 7, 2012
Last Update Posted
: April 30, 2013
University of North Carolina, Chapel Hill
Information provided by (Responsible Party):
Abbie Smith-Ryan, PhD, University of North Carolina, Chapel Hill
Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation. The physical working capacity test has been used to show significant increases in physical working capacities following supplementation. The physical working capacity tests were originally developed by Moritani et al. 1981 and Devries et al. 1982 to measure the point of onset of muscular fatigue. It is hypothesized that beta-alanine will increase physical working capacity at heart rate threshold, thereby signifying a delay in fatigue.
An equal number of men and women will be recruited [Men, n=20 (10 placebo [PL]; 10 beta-alanine (Active)]; [Women,n=20 (10 PL; 10 Active)]. Men and women will be randomly assigned to respective groups to allow for equal numbers in supplement and placebo groups.
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Ages Eligible for Study:
18 Years to 35 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Between the ages of 18-35 years old
Be recreationally active (defined as accumulating 1-5 hours of moderate intensity
Any health risks or indicators that would prevent them from participating in physical activity, as determined by a health history questionnaire
Must not have taken performance enhancing supplements containing beta-alanine or creatine during the last 3 months