Comparison of Ultrafast Echo With Echotracking
The aim is to compare a new technique for assessing mechanical properties of large arteries: the Ultrafast echo with the reference technique, the echotracking. This will be done by studying in parallel hypertensive patients and controls with both techniques and this will revisit old concepts of increased stiffness in hypertensive arteries.
Essential Untreated Hypertension
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Protocole ULTRAFAST - ECHOTRACKING : Remodelage pariétal et rigidité artérielle Chez l'Hypertendu : Nouvelle étude de Leur Relation Utilisant l'élastographie Par Ultrafast-écho et la séparation Intima/média Par écho-tracking|
- Local common carotid artery pulse wave velocity [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
- Common carotid artery Young's modulus (Stiffness of wall material) [ Time Frame: Day 1 ] [ Designated as safety issue: No ]
|Study Start Date:||March 2013|
|Study Completion Date:||August 2015|
|Primary Completion Date:||March 2015 (Final data collection date for primary outcome measure)|
Local common carotid artery pulse wave velocity is compared in patients with hypertension and healthy volunteers.
Local common carotid artery pulse wave velocity is compared in hypertension patients and healthy volunteers
Ultrafast ECHO is a new non invasive method for assessing stiffness of living tissues. It takes advantage of very fast imaging technologies (up to 20 000 images/sec) to measure the diffusion of pressure waves in the tissues. This pressure wave can be either natural (blood pressure), or generated by an very short ultrasonic impulsion at a given place. By using both modes, it is possible to have a precise cartography of tissue mechanical properties. This technique is applied to solid tissues such as breast or liver, but not yet currently to hollow tissues such as arteries. The aim of the present study is to compare the values of stiffness obtained with Ultrafast ECHO with the reference non invasive technique, the Echotracking, which measures stiffness by assessing the deformation of arteries in response to changes in blood pressure. On the physiological part, we will revisit old concepts of increased stiffness of hypertensive's arteries. Indeed, hypertension is associated with increased stiffness due to recruitement of collagen fibers, but also to chronic remodelling. We have shown before that this remodelling conducts to accumulation of arterial tissue of lesser intrinsic stiffness. The latter finding was done through models based on echotracking measurements. It will be interesting to see whether it holds true when stiffness is directly measured.
Sixty subjects (30 normotensive and30 hypertensives) will be included and studied once. Measurement will be performed in random order 3 time on the common carotid artery on both sides. Aortic stiffness will be measured by pulse wave velocity
Please refer to this study by its ClinicalTrials.gov identifier: NCT01743352
|Hopital Européen Georges Pompidou / Service de Pharmacologie|
|Paris, France, 75015|
|Principal Investigator:||Stéphane Laurent, MD, PhD||Pharmacology Department - Hopital Européen Georges Pompidou - Paris|