Glucose Metabolism Disorders and Metabolic Syndrome Before and After Primary Hip and Knee Replacement (HyTe-2)
|ClinicalTrials.gov Identifier: NCT01743313|
Recruitment Status : Suspended (Primary researcher not able to continue research at the moment.)
First Posted : December 6, 2012
Last Update Posted : August 8, 2017
|Condition or disease|
|Hyperglycemia Hypercholesterolemia Persistent Postoperative Pain Hip Replacement Knee Replacement|
|Study Type :||Observational|
|Actual Enrollment :||155 participants|
|Official Title:||Hyperglycemia in Joint Replacement Recipients: Glucose Metabolism Disorders and Metabolic Syndrome in Osteoarthritis Patients Before and After Primary Hip and Knee Replacement|
|Study Start Date :||April 2012|
|Primary Completion Date :||August 2012|
|Estimated Study Completion Date :||June 2018|
Hip and knee replacement recipients
Hip and knee replacement recipients (with osteoarthritis) enrolled previously into "Perioperative Hyperglycaemia in Primary Total Hip and Knee Replacement" study (NCT01021826).
- Change in glucose tolerance, measured using oral glucose tolerance test [ Time Frame: Baseline and 12-24 months after surgery ]The patients are grouped into three groups that are evaluated 12, 18 and ca. 24 months after surgery.
- Change in cholesterol levels (HDL, LDL, triglycerides) [ Time Frame: Baseline and 12-24 months after surgery ]
- Pain [ Time Frame: 12-24 months after surgery ]Assessed using visual analog scale. Patients are divided in three groups that are evaluated 12, 18 and 24 months after surgery.
- Change in plasma adipokine and cytokine concentrations [ Time Frame: Baseline and 12-24 months after surgery. ]
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01743313
|Coxa, Hospital for Joint Replacement|
|Tampere, Finland, 33520|
|Study Director:||Esa Jämsen, MD, PhD||Coxa, Hospital for Joint Replacement|