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Tailored Intervention to Improve Medication Adherence in Patients With Hypertension

This study has been completed.
University of Southern Denmark
Information provided by (Responsible Party):
Ulla Hedegaard, Odense University Hospital Identifier:
First received: December 4, 2012
Last updated: November 17, 2015
Last verified: November 2015
Patients with hypertension have an increased risk of stroke and myocardial infarction. However, poor adherence to treatment with antihypertensives and lipid-lowering agents occurs frequently within this patient group. The purpose of this study is to investigate whether a complex tailored intervention in a hospital setting will lead to increased medication adherence and fewer cardiovascular events when compared to a usual care group. Interventions focus on motivational interviewing, medication review and telephone follow up.

Condition Intervention
Hypertension Behavioral: Complex tailored intervention Behavioral: Usual care

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Prevention
Official Title: Pharmacist Intervention Programme in Secondary Care to Improve Medication Adherence in Patients With Hypertension

Further study details as provided by Ulla Hedegaard, Odense University Hospital:

Primary Outcome Measures:
  • Percent of patients that are at least 80% adherent (Medication possession rate > 0.8) to antihypertensives and statins [ Time Frame: One year from inclusion ]

Secondary Outcome Measures:
  • Non-persistence with antihypertensives and statins measured by percent of patients that are not supplied with medications for more than three continuous months [ Time Frame: One year from inclusion ]
  • Reduction in systolic and diastolic blood pressure [ Time Frame: One year from inclusion ]
  • Composite endpoint (stroke, myocardial infarction or cardiovascular death) [ Time Frame: One year from inclusion ]

Enrollment: 532
Study Start Date: December 2012
Study Completion Date: September 2014
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: Usual care
Usual care
Behavioral: Usual care
Experimental: Complex tailored intervention

The interventions consists of 3 elements:

  1. Medication review with recommendations focused on antihypertensives and statins and adherence to guidelines and patient´s adherence to medications
  2. Consultation with a pharmacist using motivational interviewing techniques
  3. Follow-up telephone calls one month and six months after inclusion
Behavioral: Complex tailored intervention


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

Age: 18 years or older

  • Patients receiving ambulatory treatment for hypertension in a hospital setting
  • The patient or a carer usually dispenses the patient's medications
  • Patient lives in the Southern Region of Denmark
  • Written consent

Exclusion Criteria:

  • Lives in a care home or institution
  • Receive dose dispensed medicine from a pharmacy
  • Medicine is dispensed by a nurse in the patient's home
  • Correctional mental health patients
  Contacts and Locations
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Please refer to this study by its identifier: NCT01742923

Odense University Hospital
Odense C, Denmark, 5000
Sponsors and Collaborators
Odense University Hospital
University of Southern Denmark
  More Information

Responsible Party: Ulla Hedegaard, PhD student, MSc (pharm), Odense University Hospital, Odense University Hospital Identifier: NCT01742923     History of Changes
Other Study ID Numbers: AKF-384
Study First Received: December 4, 2012
Last Updated: November 17, 2015

Keywords provided by Ulla Hedegaard, Odense University Hospital:
medication adherence
motivational interviewing

Additional relevant MeSH terms:
Vascular Diseases
Cardiovascular Diseases processed this record on September 25, 2017