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The primary aim of this study is to determine the safest and most effective therapeutic strategy to decrease the incidence of postoperative atrial fibrillation following cardiac surgery in an era with shorter ICU and hospital length of stay. A secondary goal is to evaluate the length of hospital stay associated with each treatment strategy.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
adult patients undergoing open heart surgery
age > or = to 18 years
undergoing either coronary artery bypass graft surgery (CABG), valvular heart surgery or a combined procedure
received a class-I or class-III antiarrhythmic agent in the past six months
had second or third degree heart block
had a resting heart rate of less than 50 beats per minute
had a systolic blood pressure less than 100 mmHg
had severe asthma or severe chronic obstructive pulmonary disease
had uncontrolled heart failure
had a serum aspartate aminotransferase or alanine aminotransferase concentration greater than four times the upper limit of normal