Ultraviolet-A and Riboflavin Treatment for Infectious Keratitis

This study has been completed.
Information provided by (Responsible Party):
ClinicalTrials.gov Identifier:
First received: November 27, 2012
Last updated: August 18, 2015
Last verified: August 2015
This study is to evaluate the efficacy of ultraviolet-A (UVA) and riboflavin application (also often referred to as corneal collagen crosslinking) as a method to enhance treatment of infectious keratitis.

Condition Intervention
Infectious Keratitis
Other: Ultraviolet-A and riboflavin

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Ultraviolet-A and Riboflavin Treatment for Infectious Keratitis

Resource links provided by NLM:

Further study details as provided by Cxlusa:

Primary Outcome Measures:
  • Resolution of Signs and Symptoms of Infectious Keratitis [ Time Frame: Subjects will be followed until resolution of signs and symptoms, an expected average of 8 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 1000
Study Start Date: August 2011
Study Completion Date: July 2014
Primary Completion Date: July 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Ultraviolet-A and riboflavin Other: Ultraviolet-A and riboflavin


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  1. Subjects must be 18 years of age or older.
  2. Ability to provide written informed consent.
  3. Likely to complete all study visits.
  4. Subjects must have one eye that with a diagnosis of infectious keratitis.

Exclusion Criteria:

  1. A corneal perforation.
  2. Descemetocele.
  3. Pregnancy or breastfeeding.
  4. Active Herpes corneal disease.
  5. Patient is unwilling or unable to comply with a medication regimen and follow up appointments.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01739673

United States, Arizona
Schwartz Laser Eye Center
Scottsdale, Arizona, United States
United States, California
Davidorf Eye Group
West Hills, California, United States
United States, Colorado
Corneal Consultants of Colorado, PC
Littleton, Colorado, United States
United States, Florida
Center for Excellence in Eye Care
Miami, Florida, United States
United States, Minnesota
Minnesota Eye Consultants
Minneapolis, Minnesota, United States
United States, Missouri
Ophthalmology Associates
St. Louis, Missouri, United States
Sponsors and Collaborators
Study Director: William Trattler, MD Center For Excellence In Eye Care
  More Information

Responsible Party: Cxlusa
ClinicalTrials.gov Identifier: NCT01739673     History of Changes
Other Study ID Numbers: iCXL 
Study First Received: November 27, 2012
Last Updated: August 18, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Cxlusa:
Infectious Keratitis

Additional relevant MeSH terms:
Communicable Diseases
Corneal Diseases
Eye Diseases
Dermatologic Agents
Growth Substances
Photosensitizing Agents
Physiological Effects of Drugs
Vitamin B Complex

ClinicalTrials.gov processed this record on May 26, 2016