Nutritional Risk Factors for Hip Fracture: a Case Control Study

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01738776
Recruitment Status : Completed
First Posted : November 30, 2012
Last Update Posted : December 4, 2012
University of Oslo
Information provided by (Responsible Party):
Anne Torbergsen, Oslo University Hospital

Brief Summary:
Low Body Mass Index (BMI) is a risk factor for hip fracture, but it is unknown if it is the low BMI per se that increases risk of hip fracture or if specific micro-nutrients contribute. The investigators want to elucidate this aspect in a case control study studying micronutrients in serum and bone turnover markers of hip fracture patients compared with controls of the same age.

Condition or disease
Hip Fracture

Study Type : Observational
Actual Enrollment : 184 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Nutritional Risk Factors for Hip Fracture: a Case Control Study
Study Start Date : September 2009
Primary Completion Date : April 2011
Study Completion Date : April 2011

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Hip fracture patients participating in a randomised controlled trial (RCT) of orthogeriatric care ( NCT01009268)
A group of voluntary elderly persons without a history of hip fracture, recruited specifically for this purpose

Primary Outcome Measures :
  1. micronutrient association with increased risk of hip fracture [ Time Frame: At admission ]
    Blood was drawn for micronutrient analysis in hip fracture patients and in controls

Secondary Outcome Measures :
  1. Are micronutrients related to bone turnover markers [ Time Frame: At admission ]
    Blood was drawn for bone turnover analysis. Correlation analysis with micronutrients was performed

Biospecimen Retention:   Samples With DNA
For vitamin and hormone analysis serum was collected For some vitamin analysis EDTA blood was collected For RNA analysis fullblood was collected

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Ages Eligible for Study:   Child, Adult, Senior
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Cases: The first 116 patients of an ongoing RCT were included consecutively and examined by blood samples pre operatively for nutrition and hormone analysis. The catchment area for the cases was the city of Oslo, Norway.

A control group, at the same age with no history of hip fracture, was drawn at random from inhabitants aged 60 - 100 years (median age 82 years) at the census files of Oslo in 2005.


Inclusion Criteria:

Cases are admitted acutely for a femoral neck fracture, a trochanteric or a subtrochanteric femoral fracture.

Exclusion Criteria:

  • Hip fracture as part of multi-trauma or high energy trauma (defined as a fall from a higher level than 1 metre). One recent fracture in addition to the hip fracture (e.g. radius or shoulder) is acceptable.
  • Regarded as moribund at admittance.
  • Absence of a valid informed consent or assent.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01738776

University of Oslo, Institute of Clinical Medicine
Oslo, Norway, 0424
Sponsors and Collaborators
Oslo University Hospital
University of Oslo
Study Chair: Morten Mowe, PhD Oslo University Hospital

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Anne Torbergsen, Clinical Nutritionist, Oslo University Hospital Identifier: NCT01738776     History of Changes
Other Study ID Numbers: S-0916901(REK)
120000MM ( Other Grant/Funding Number: Oslo University Hospital )
First Posted: November 30, 2012    Key Record Dates
Last Update Posted: December 4, 2012
Last Verified: November 2012

Keywords provided by Anne Torbergsen, Oslo University Hospital:
hip fracture
risk factors
vitamin K1
vitamin D
bone turnover markers
undercarboxylated osteocalcin
bone specific alkaline phosphatase (BALP)
insulin like growth factor 1 (IGF1)
parathyroid hormone (PTH)

Additional relevant MeSH terms:
Fractures, Bone
Hip Fractures
Wounds and Injuries
Femoral Fractures
Hip Injuries
Leg Injuries