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Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Val Lowe, Mayo Clinic Identifier:
First received: November 27, 2012
Last updated: July 18, 2017
Last verified: July 2017
Aging is associated with a loss of brain function and conditions such as dementia and Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the progression of age related degenerative diseases. Aerobic exercise training can increase brain volumes and is associated with decreased risk for degenerative brain conditions. However, little is know about the changes that occur to brain metabolism with aerobic training and aging.

Condition Intervention
Dementia Behavioral: High intensity aerobic training Behavioral: Sedentary Control

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism

Resource links provided by NLM:

Further study details as provided by Val Lowe, Mayo Clinic:

Primary Outcome Measures:
  • Change in Brain Glucose Uptake [ Time Frame: 12 weeks ]
    The investigators will assess brain glucose uptake using positron emission tomography at baseline and following 12-weeks of either aerobic exercise training or sedentary control period.

Estimated Enrollment: 40
Study Start Date: October 2012
Estimated Study Completion Date: December 2019
Estimated Primary Completion Date: June 2019 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise
Aerobic exercise
Behavioral: High intensity aerobic training
High intensity aerobic interval training will be performed 12-weeks. Exercise training will last 1 hour per day, 5 days per week and include high intensity interval cycling at ~70-95% maximum workload for 4 minutes followed by 3 minutes of rest.
Behavioral: Sedentary Control
Sedentary control participants will not perform any regular exercise for 12-weeks.


Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible. Pregnant women, children, prisoners or other at risk populations will not be recruited.

Inclusion Criteria:

  • Age 18-30 years or 65-80 years

Exclusion Criteria:

  • Body mass index (BMI) >31 kg/m2
  • Smoking
  • Pregnancy
  • Participation in structured exercise (>2 times per week for 30 minutes or longer)
  • Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110 mg/dL and untreated hypo- or hyperthyroidism) or renal disease
  • Orthopedic problems that would keep them from being able to ride an exercise bicycle, lift weights or do a combination of these exercise
  • Medications that are known to impact on mitochondrial function: Corticosteroids, opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas, insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma agonist)
  • Claustrophobia
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01738568

United States, Minnesota
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Principal Investigator: Val Lowe, MD Mayo Clinic
  More Information

Responsible Party: Val Lowe, PI, Mayo Clinic Identifier: NCT01738568     History of Changes
Other Study ID Numbers: 12-003357
Study First Received: November 27, 2012
Last Updated: July 18, 2017

Keywords provided by Val Lowe, Mayo Clinic:
High intensity aerobic training

Additional relevant MeSH terms:
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurocognitive Disorders
Mental Disorders processed this record on September 21, 2017