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Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells (Diag-iPS)

This study has been terminated.
Information provided by (Responsible Party):
Nantes University Hospital Identifier:
First received: November 22, 2012
Last updated: November 6, 2014
Last verified: November 2014
The recent developments of research on iPS (induced pluripotent stem) cells lead to the establishment of mature cell lines such as cardiomyocytes or valvular interstitial cells with genetic and cellular characteristics of the donors. These cells represent a biological material more readily available to identify the pathophysiological mechanisms involved in the diseases of BrS or ERS patients, which will lead to the identification of genetic markers.

Condition Intervention
Inherited Arrhythmias and Valvulopathies
Other: Skin biopsies

Study Type: Interventional
Study Design: Masking: Open Label
Official Title: Molecular Mechanism Identification in Inherited Arrhythmias and Valvulopathies From Induced Pluripotent Stem Cells

Resource links provided by NLM:

Further study details as provided by Nantes University Hospital:

Primary Outcome Measures:
  • Production of cardiomyocytes modele from skin fibroblast of arrhythmic patient

Secondary Outcome Measures:
  • Production of valve interstitial cells modele from skin fibroblast of patient with a valvulopathy

Estimated Enrollment: 20
Study Start Date: November 2011
Study Completion Date: November 2014
Primary Completion Date: November 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
inherited arrhythmias
6 patient with inherited arrhythmias
Other: Skin biopsies
6 patient with valvulopathies
Other: Skin biopsies
8 healthy people for these pathologies
Other: Skin biopsies


Ages Eligible for Study:   22 Years to 60 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion criteria:

  • Patient with a family history of inherited arrhythmia or valvulopathy
  • Age : 22-60 yo.
  • patient no confine to bed
  • Male or female
  • Written consent
  • Patient affiliated to the French social security

Exclusion criteria:

  • Pregnant woman
  • Patient under 22 yo or adults under guardianship
  • Indication against local anesthesia
  • Anticoagulant treatment
  • Absence or positivity of HIV, HBV, HCV serology
  Contacts and Locations
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Please refer to this study by its identifier: NCT01734356

Nantes University Hospital
Nantes, France
Sponsors and Collaborators
Nantes University Hospital
Principal Investigator: Vincent PROBST Nantes UH
  More Information

Responsible Party: Nantes University Hospital Identifier: NCT01734356     History of Changes
Other Study ID Numbers: BRD/10/11-P
Study First Received: November 22, 2012
Last Updated: November 6, 2014

Keywords provided by Nantes University Hospital:

Additional relevant MeSH terms:
Heart Valve Diseases
Heart Diseases
Cardiovascular Diseases processed this record on May 22, 2017