Stereotactic Radiosurgery for Essential Tremor and Parkinsonian Tremor
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The purpose of this study is to determine the changes in quality of life and degree of tremor for patients with essential tremor or Parkinsonian tremor who are treated by stereotactic radiosurgery (SRS). This is a questionnaire-based study. Please see Detailed Description below for more information.
Condition or disease
TremorEssential TremorParkinson DiseaseRadiosurgeryQuality of Life
The tremor-related quality of life for each patient will be assessed by self-assessment questionnaire at 3 month intervals for 1 year after treatment by stereotactic radiation.
Secondary Outcome Measures :
Severity of Tremor [ Time Frame: 1 year ]
The severity of tremor will be assessed by objective measure (Fahn-Tolosa-Marin tremor rating scale) at 3 month intervals for 1 year following the stereotactic radiation treatment.
Neuropsychological Assessment [ Time Frame: Baseline and 6 months post-treatment ]
All patients will undergo a neuropsychological assessment (1-2 hr examination) at baseline and at 6 months post-treatment. This will assess any unanticipated changes in neuropsychological brain function.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
This trial enrolls persons with essential tremor or Parkinsonian tremor that is inadequately controlled by medications.
Must be certified by a neurologist as having essential tremor or Parkinsonian tremor that is insufficiently controlled by medication alone.
Preference to receive radiation treatment for tremor treatment, rather than surgical DBS implantation or surgical thalamotomy
At least 18 years old
Contraindications to cranial radiation (such as prior radiation to the thalamus)
Inability to have a MRI of the brain
Prior surgical thalamotomy treatment (but contralateral deep brain stimulator [DBS] is permitted)