Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D
Recruitment status was Recruiting
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
|Official Title:||Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D|
- Upper airway elasticity [ Time Frame: 10 - 40 seconds ] [ Designated as safety issue: No ]
The investigators will determine elasticity of the upper airway during induced central apneas by dividing the change in airway pressure by the change in airway cross-sectional area.
The time frame for the outcome of this study is equal to the duration of the induced central sleep apnea (usually less than 40 seconds).
|Study Start Date:||December 2012|
|Estimated Study Completion Date:||December 2014|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
|Experimental: Viscoelastic properties of the airway||Other: Induced central apneas|
In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms that lead to airway closure are not completely understood. Some studies have shown that there is progressive narrowing of the pharyngeal airway across breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea.
The investigators will test how the viscoelastic properties of the airway influence PEN. To this end, the investigators will visualize the pharynx of sleep apnea patients using a thin endoscope and will induce central apneas during sleep. Pharyngeal cross-sectional area will be recorded during incremental changes in pharyngeal pressure during central apneas.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01733784
|Contact: Pedro R Genta, MD||(617) firstname.lastname@example.org|
|Contact: Lauren B Hess, BS||(617) email@example.com|
|United States, Massachusetts|
|Brigham and Women's Hospital||Recruiting|
|Boston, Massachusetts, United States, 02115|
|Contact: Pedro R Genta, MD 617-732-6541 firstname.lastname@example.org|
|Contact: Lauren B Hess, BS (617) 732-8976 email@example.com|
|Sub-Investigator: Pedro R Genta, MD|
|Principal Investigator:||David A Wellman, MD||Brigham and Women's Hospital|