Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.
Dose and duration of bisphosphonate therapy will increase the likelihood that patients experience delayed healing of non-union fractures.
Non-union or Delayed Healing Fractures
|Study Design:||Time Perspective: Retrospective|
|Official Title:||Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.|
- The number of patients with delayed healing or non-union fractures with prior bisphosphonate use [ Time Frame: 01/01/2000 - 12/31/2011 ] [ Designated as safety issue: Yes ]This variable will be generated by reviewing diagnosis codes from patients seen at the University of Wisconsin Hospital and Clinics during the time period identified above.
- Evaluation of patient variables (demographic or medical history) related to non-union or delayed healing fractures. [ Time Frame: 1/1/2000-12-31-2012 ] [ Designated as safety issue: No ]Patients with non-union or delayed healing fractures obtaining care at the University of Wisconsin Hospital or Clinics will have a medical record review conducted.
|Study Start Date:||November 2012|
|Study Completion Date:||July 2013|
|Primary Completion Date:||March 2013 (Final data collection date for primary outcome measure)|
Prior bisphosphonate users
Patients with record of using bisphosphonate medication
We intend to review the UWHealth patient database to identify individuals with delayed or nonunion fractures. Subsequently, we will collect associated medical information related to fractures such as age of osteoporosis diagnosis, BMI, previous bisphosphonate treatment, type and location of fracture, time to complete union, other treatment needed for nonunion etc. With this information, we will evaluate the risk of delayed and nonunion fractures in patients previously receiving bisphosphonate treatment compared to a normal population. We also will investigate other potential causes of delayed or nonunion fractures in this population.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01731535
|United States, Wisconsin|
|University of Wisconsin|
|Madison, Wisconsin, United States, 53705|
|Study Director:||Neil Binkley, MD||University of Wisconsin, Madison|