The Learning and Memory of the Experience of Pain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01731314
Recruitment Status : Active, not recruiting
First Posted : November 21, 2012
Last Update Posted : August 29, 2017
Information provided by (Responsible Party):
Jian Kong, Massachusetts General Hospital

Brief Summary:
This study investigates the learning and memory of pain.

Condition or disease Intervention/treatment Phase
Pain Behavioral: Learning and Memory of Pain Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Other
Study Start Date : January 2013
Estimated Primary Completion Date : January 2018
Estimated Study Completion Date : January 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Memory
U.S. FDA Resources

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  1. Male and female healthy volunteers.
  2. 18-65 years of age.
  3. Right-handed.
  4. Fluency in English. Ability to read and understand English; English can be a second language provided that the participant feels that he/she is able to understand all the questions used in the assessment measures.

Exclusion Criteria:

  1. Any previous experience with conditioned analgesia/hyperalgesia paradigms.
  2. Presence of any illness or medication use that is judged to interfere with the trial. For example: psychiatric disorder according to the DSM-IV manual, medication that can influence cognition or emotional processing, i.e. sleep medication, antidepressants, anti-convulsants or opioids.
  3. Unwillingness to receive brief pain stimulation administered by a heat probe on the hand.
  4. Instability of responses to experimental heat pain
  5. Any contraindications to fMRI scanning for subjects in Experiment 2 (including metal implants, claustrophobia, history of head trauma, and pregnancy).
  6. Peripheral neuropathy.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01731314

United States, Massachusetts
MGH East Campus, 149 13th St.
Charlestown, Massachusetts, United States, 02129
Sponsors and Collaborators
Massachusetts General Hospital

Responsible Party: Jian Kong, MS, MD, Massachusetts General Hospital Identifier: NCT01731314     History of Changes
Other Study ID Numbers: 2012P002386
First Posted: November 21, 2012    Key Record Dates
Last Update Posted: August 29, 2017
Last Verified: June 2015