Optical Detection of Malignancy During Percutaneous Interventions
|Pulmonary Coin Lesion Colon Cancer Liver Metastasis Breast Cancer||Procedure: Core biopsy procedure|
|Study Design:||Observational Model: Case-Only
Time Perspective: Cross-Sectional
|Official Title:||Discrimination of Benign and Malignant Human Tissue During Percutaneous Interventions Using Optical Spectroscopy Techniques|
- Differentiation between normal and malignant tissue [ Time Frame: Day 0 ]Statistical analysis of the difference between diffuse reflectance spectra obtained at normal and malignant measurement locations
Biospecimen Retention: Samples Without DNA
|Study Start Date:||October 2012|
|Study Completion Date:||December 2015|
|Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Histological biopsy procedures
Patients with a suspicious lesion in lung or liver or breast who are planned for a standard core biopsy procedure. And patients planned for percutaneous RFA (Radiofrequency Ablation) of colorectal liver metastasis
Procedure: Core biopsy procedure
Core biopsy of suspicious lesion in lung, liver, breast, or colorectal liver metastasis.
In this observational study the investigators aim to evaluate whether optical spectroscopy can correctly diagnose malignant tissue in the existing clinical workflow of percutaneous interventions in lung, liver, and breast.
During the measurement procedure, possible improvements of the measurement hardware will be recorded. Analysis of this documentation will provide information for possible alterations of hardware design for improved clinical applicability in the future. Special attention will be paid to observe how the procedure fits in the standard workflow of the radiologist.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01730365
|Nederlands Kanker Instituut/Antonie van Leeuwenhoek Ziekenhuis|
|Amsterdam, Noord-Holland, Netherlands, 1066 CX|
|Principal Investigator:||Theo Ruers, MD||Nederlands Kanker Instituut/Antonie van leeuwenhoek Ziekenhuis|