Cerebellum - Cognitive Outcome and Functional Connectivity

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01730274
Recruitment Status : Unknown
Verified November 2012 by Christian Dorfer, Medical University of Vienna.
Recruitment status was:  Not yet recruiting
First Posted : November 21, 2012
Last Update Posted : November 21, 2012
Information provided by (Responsible Party):
Christian Dorfer, Medical University of Vienna

Brief Summary:

Aim: To investigate the effect of cerebellar tumor surgery on the resting state functional connectivity level in higher order cognition networks known to interact with the cerebellum. Furthermore, to correlate the connectivity level of these networks with the neuropsychological performance and functional outcome of the patients.

The investigator's hypothesis is that the functional connectivity of various cognition networks in the cerebrum as assessed by resting-state functional magnetic resonance imaging can be impaired after cerebellar tumor surgery and can be correlated with the neuropsychological performance. The effect of surgery on the cognition networks and the neuropsychological performance is dependent on the tumor location within the cerebellum. Such a correlation seems feasible as functional connectivity analysis could be correlated with the neuropsychological impairment in various neuropsychiatric disorders. Furthermore, investigators were able to depict the maturation of the functional connectivity networks in parallel to the neurocognitive development in childhood

Condition or disease
Childhood Cerebellar Tumor

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Cerebellar Tumors of Childhood - Impact on Cognition and Functional Connectivity
Study Start Date : January 2013
Estimated Primary Completion Date : January 2015
Estimated Study Completion Date : January 2015

children operated on a cerebellar tumor
healthy subjects
healthy volunteers

Primary Outcome Measures :
  1. neuropsychological assessment [ Time Frame: up to 24 months ]

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Ages Eligible for Study:   15 Years to 30 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
young adolescent operated on a cerebellar tumor as a child

Inclusion Criteria:

  • • Male or female patients aged > 15 yrs

    • Age at surgery between 1 yrs - 12 yrs
    • Compliance (the patients have to be able to lay motionless in a 3 Tesla MR scanner and to cooperate with the examiner during the examination)
    • Signed informed consent from the patient and/or the parents

Exclusion Criteria:

  • • Patients with Neurofibromatosis 1

    • Severe visual or auditory impairment
    • Cerebrospinal fluid shunt device
    • Prior radiotherapy or chemotherapy
    • Contraindications to MRI

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01730274

Contact: Christian Dorfer, MD 0043140400 ext 4560

MUV, Department of Neurosurgery Not yet recruiting
Vienna, Austria, 1090
Contact: Christian Dorfer, MD   
Sponsors and Collaborators
Medical University of Vienna
Principal Investigator: Christian Dorfer, MD MUV, Department of Neurosurgery

Responsible Party: Christian Dorfer,, Medical University of Vienna Identifier: NCT01730274     History of Changes
Other Study ID Numbers: cerebellum 1.1
KLI 252 ( Other Grant/Funding Number: Austrian Science Fund )
First Posted: November 21, 2012    Key Record Dates
Last Update Posted: November 21, 2012
Last Verified: November 2012

Additional relevant MeSH terms:
Cerebellar Neoplasms
Infratentorial Neoplasms
Brain Neoplasms
Central Nervous System Neoplasms
Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Cerebellar Diseases