Cerebellum - Cognitive Outcome and Functional Connectivity

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2012 by Medical University of Vienna.
Recruitment status was  Not yet recruiting
Information provided by (Responsible Party):
Christian Dorfer, Medical University of Vienna
ClinicalTrials.gov Identifier:
First received: November 15, 2012
Last updated: November 20, 2012
Last verified: November 2012

Aim: To investigate the effect of cerebellar tumor surgery on the resting state functional connectivity level in higher order cognition networks known to interact with the cerebellum. Furthermore, to correlate the connectivity level of these networks with the neuropsychological performance and functional outcome of the patients.

The investigator's hypothesis is that the functional connectivity of various cognition networks in the cerebrum as assessed by resting-state functional magnetic resonance imaging can be impaired after cerebellar tumor surgery and can be correlated with the neuropsychological performance. The effect of surgery on the cognition networks and the neuropsychological performance is dependent on the tumor location within the cerebellum. Such a correlation seems feasible as functional connectivity analysis could be correlated with the neuropsychological impairment in various neuropsychiatric disorders. Furthermore, investigators were able to depict the maturation of the functional connectivity networks in parallel to the neurocognitive development in childhood

Childhood Cerebellar Tumor

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Cerebellar Tumors of Childhood - Impact on Cognition and Functional Connectivity

Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • neuropsychological assessment [ Time Frame: up to 24 months ] [ Designated as safety issue: No ]

Estimated Enrollment: 40
Study Start Date: January 2013
Estimated Study Completion Date: January 2015
Estimated Primary Completion Date: January 2015 (Final data collection date for primary outcome measure)
children operated on a cerebellar tumor
healthy subjects
healthy volunteers


Ages Eligible for Study:   15 Years to 30 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
young adolescent operated on a cerebellar tumor as a child

Inclusion Criteria:

  • • Male or female patients aged > 15 yrs

    • Age at surgery between 1 yrs - 12 yrs
    • Compliance (the patients have to be able to lay motionless in a 3 Tesla MR scanner and to cooperate with the examiner during the examination)
    • Signed informed consent from the patient and/or the parents

Exclusion Criteria:

  • • Patients with Neurofibromatosis 1

    • Severe visual or auditory impairment
    • Cerebrospinal fluid shunt device
    • Prior radiotherapy or chemotherapy
    • Contraindications to MRI
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01730274

Contact: Christian Dorfer, MD 0043140400 ext 4560 christian.dorfer@meduniwien.ac.at

MUV, Department of Neurosurgery Not yet recruiting
Vienna, Austria, 1090
Contact: Christian Dorfer, MD       christian.dorfer@meduniwien.ac.at   
Sponsors and Collaborators
Medical University of Vienna
Principal Investigator: Christian Dorfer, MD MUV, Department of Neurosurgery
  More Information

Responsible Party: Christian Dorfer, Dr.med.univ., Medical University of Vienna
ClinicalTrials.gov Identifier: NCT01730274     History of Changes
Other Study ID Numbers: cerebellum 1.1  KLI 252 
Study First Received: November 15, 2012
Last Updated: November 20, 2012
Health Authority: Austria: Agency for Health and Food Safety

Additional relevant MeSH terms:
Cerebellar Diseases
Cerebellar Neoplasms
Brain Diseases
Brain Neoplasms
Central Nervous System Diseases
Central Nervous System Neoplasms
Infratentorial Neoplasms
Neoplasms by Site
Nervous System Diseases
Nervous System Neoplasms

ClinicalTrials.gov processed this record on May 30, 2016