Near Infrared Spectroscopy in Children With Autism and ADHD
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|ClinicalTrials.gov Identifier: NCT01730079|
Recruitment Status : Terminated
First Posted : November 21, 2012
Last Update Posted : July 2, 2017
- Near-infrared spectroscopy (NIRS) is a functional imaging technique that can be uses light to study brain function while allowing for movement. To look at blood flow in the brain, NIRS uses a low-power light source with detectors that see how the light changes as it passes through brain tissue. Brain blood flow can indicate which parts of the brain are active during different tasks. Researchers want to study children with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASD) and will use NIRS to compare the blood flow in the brain of children with ADHD and ASD with that of typically developing children.
- To see how well NIRS can detect changes in brain blood flow during tests of thinking and memory in children.
- To compare blood flow in the brains of typically developing children and those with ADHD or ASD.
- Children between 4 and 8 years of age with ASD, ADHD, or children with no psychiatric diagnoses.
- Participants will be screened for eligibility. Those who are taking stimulant medication for ADHD or ASD will need to stop taking it for 3 days before the study visit.
- After participating in a screening assessment, all participants will have one study visit. At this visit, they will have be asked to complete two tasks during a NIRS scan. For both tasks, they will react to images on a computer screen. This visit will last about 2 hours.
- This is a testing study only. No blood or other samples will be needed for this study.
|Condition or disease|
|Attention Deficit Disorder With Hyperactivity Attention Deficit Disorder Attention Deficit Hyperactivity Disorder Autism Autism Spectrum Disorders|
Objective: to test whether Near Infra-Red Spectroscopy (NIRS) can be used to monitor cognitive brain function and detect markers for differentiation of Autism Spectrum Disorders (ASD) and Attention Deficit Hyperactivity Disorder (ADHD).
Study population: Children with ASD, ADHD, and typically developing children, all between 4 and 8 years of age.
Design: The study will investigate NIRS signal changes while children with ASD, ADHD, and typically developing children perform well-known functional tasks.
Outcome Measures: Graded changes in blood flow and oxygen, measured with NIRS, in response to different functional tasks.
|Study Type :||Observational|
|Actual Enrollment :||42 participants|
|Official Title:||Near Infra-Red Spectroscopy (NIRS) in Neurodevelopmental Disorders and Typically Developing Children|
|Study Start Date :||October 23, 2012|
|Actual Primary Completion Date :||April 11, 2017|
|Actual Study Completion Date :||April 11, 2017|
- Graded changes in blood flow and oxygen, measured with NIRS, in response to different functional tasks.
- Differential activity according to region of the frontal cortext and task elements.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01730079
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike|
|Bethesda, Maryland, United States, 20892|
|Principal Investigator:||Audrey E Thurm, Ph.D.||National Institute of Mental Health (NIMH)|