Neurohormonal Parameters in Hypertrophic Cardiomyopathies (REEF-CMH)
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The primary purpose of this study is to demonstrate that changes in plasma levels of circulating neurohormones (mainly BNP and NT-proBNP), measured at rest and post-exercise correlate with exercise functional limitation (assessed by exercise peak VO2) and exercise ultrasonic parameters (as left ventricular filling, obstruction, and mitral regurgitation)
The secondary purposes are to study the kinetics of secretions of natriuretic peptides, and their relationships with extent of MRI myocardial fibrosis with the degree of exercise functional limitation.
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Ages Eligible for Study:
18 Years to 75 Years (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
- Age 18 to 75 years
Primary (sarcomeric) hypertrophic cardiomyopathy, obstructive or non obstructive, with studies of exercise peak oxygen consumption and cardiac MRI with gadolinium late-enhancement
Patient with a social insurance Patient at rest
- Age 18 to 75 years
Primary (sarcomeric) hypertrophic cardiomyopathy, obstructive or non obstructive
Patient with a social insurance
- Insufficient echogenicity
Permanent atrial fibrillation
Complete BBB on the ECG
LVEF < 35 %
Previous septal ablation (surgical or percutaneous)
Simultaneous participation to another biomedical research
If exercise needed:
contraindication to exercise : hemodynamic instability, uncontrolled high blood pressure (>220/120 mmHg), severe aortic stenosis
Inability to exercise (muscular, pulmonary, elderly patient)