Metabolism Associated With Abdominal Fat Mass Distribution
The primary objective of this clinical trial is to characterize metabolic signatures associated with abdominal fat distribution in 40 women with different BMI 29-40 and different abdominal distribution of fat (visceral vs. sub-cutaneous fat).
No intervention with a product is planned. The subjects will be given one high fat meal with commercial products (eggs, milk, cream, bread, fruits, cheese and cheese) on one test day to test the post-prandial metabolic response.
|Official Title:||Metabolism Associated With Abdominal Fat Mass Distribution|
- Metabolic plasma, urine and faeces profiles as a function of fat mass distribution [ Time Frame: Changes from baseline in metabolic profiles at one day following fat meal intake ] [ Designated as safety issue: No ]
Metabolic profiles of plasma, urine and feces samples are obtained by Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry.
Fat mass distribution is assessed using CT scan and DXA (Dual X-Ray Energy Absorptiometry).
- Insulin sensitivity [ Time Frame: Measured on the day before the fat meal intake ] [ Designated as safety issue: No ]Insulin sensitivity is measured by oral glucose tolerance test
- Basal Energy Expenditure [ Time Frame: Basal Energy Expenditure is measured on the day preceding the fat meal intake ] [ Designated as safety issue: No ]Basal Energy Expenditure is measured by indirect calorimetry
|Study Start Date:||September 2008|
|Study Completion Date:||April 2012|
|Primary Completion Date:||October 2009 (Final data collection date for primary outcome measure)|
No product is tested
Please refer to this study by its ClinicalTrials.gov identifier: NCT01726647
|Nestlé Clinical Development Unit / Metabolic Unit|
|Lausanne 26, Switzerland, 1000|
|University Hospitals, Service of endocrinology, diabetology, and metabolism|
|Lausanne, Switzerland, 1011|
|Principal Investigator:||Vittorio Giusti, MD, PD/MER||University Hospitals of Lausanne|