Metabolism Associated With Abdominal Fat Mass Distribution
|ClinicalTrials.gov Identifier: NCT01726647|
Recruitment Status : Completed
First Posted : November 15, 2012
Last Update Posted : November 15, 2012
The primary objective of this clinical trial is to characterize metabolic signatures associated with abdominal fat distribution in 40 women with different BMI 29-40 and different abdominal distribution of fat (visceral vs. sub-cutaneous fat).
No intervention with a product is planned. The subjects will be given one high fat meal with commercial products (eggs, milk, cream, bread, fruits, cheese and cheese) on one test day to test the post-prandial metabolic response.
|Condition or disease|
|Study Type :||Observational|
|Actual Enrollment :||40 participants|
|Official Title:||Metabolism Associated With Abdominal Fat Mass Distribution|
|Study Start Date :||September 2008|
|Primary Completion Date :||October 2009|
|Study Completion Date :||April 2012|
No product is tested
- Metabolic plasma, urine and faeces profiles as a function of fat mass distribution [ Time Frame: Changes from baseline in metabolic profiles at one day following fat meal intake ]
Metabolic profiles of plasma, urine and feces samples are obtained by Nuclear Magnetic Resonance spectroscopy and Mass Spectrometry.
Fat mass distribution is assessed using CT scan and DXA (Dual X-Ray Energy Absorptiometry).
- Insulin sensitivity [ Time Frame: Measured on the day before the fat meal intake ]Insulin sensitivity is measured by oral glucose tolerance test
- Basal Energy Expenditure [ Time Frame: Basal Energy Expenditure is measured on the day preceding the fat meal intake ]Basal Energy Expenditure is measured by indirect calorimetry
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01726647
|Nestlé Clinical Development Unit / Metabolic Unit|
|Lausanne 26, Switzerland, 1000|
|University Hospitals, Service of endocrinology, diabetology, and metabolism|
|Lausanne, Switzerland, 1011|
|Principal Investigator:||Vittorio Giusti, MD, PD/MER||University Hospitals of Lausanne|