Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps
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ClinicalTrials.gov Identifier: NCT01725321 |
Recruitment Status
:
Completed
First Posted
: November 12, 2012
Last Update Posted
: May 29, 2015
|
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Although colonoscopy is considered the gold standard for diagnosis of colonic polyps, the missed rate for colonic adenoma ranged from 15-32%. In particular, missed colonic polyps in the right side colon have been suggested to be the cause for interval cancer that developed after a prior negative colonoscopy.
Different endoscopic image enhanced modules like the narrow band imaging (NBI) have been developed to improve colonic polyp detection. However, it remains controversial whether the previous version of NBI helps to improve colonic polyp detection. The new generation colonoscope is equipped with high definition and improved narrow band imaging (NBI) which gives at least twice the viewable distance and contrast. The images obtained are far brighter with better resolution than the previous version. It however remains to be determined whether this enhanced imaging technique could help to improve colonic polyps detection.
Hypothesis:
The new generation NBI increases the detection rate of proximal serrated polyps and reduces the missed rate of all colorectal polyps.
Aims:
- To determine whether the new generation NBI improve the detection rate of proximal serrated polyps.
- To determine whether the new generation NBI improve the detection rate of all colorectal adenoma and polyps.
- To determine whether the new generation NBI reduce the miss rate of colorectal adenoma and polyps.
Condition or disease | Intervention/treatment |
---|---|
Colonic Neoplasm | Other: Narrow band imaging |
Design:
Prospective randomized trial
Inclusion:
• All patients scheduled to have screening or scheduled colonoscopy
Exclusion:
- History of Crohn's or ulcerative colitis
- Surveillance for known polyposis syndrome (FAP or HNPCC)
- Previous colonic resection (except appendectomy)
- Refused consent
- Deranged coagulation profile that preclude polypectomy
Study Type : | Observational |
Actual Enrollment : | 360 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Official Title: | Colonoscopy With Narrow Band Imaging for Diagnosis of Proximal Serrated Polyps |
Study Start Date : | October 2012 |
Actual Primary Completion Date : | September 2013 |
Actual Study Completion Date : | October 2013 |
Group/Cohort | Intervention/treatment |
---|---|
Narrow band imaging
Colonoscopy with new narrow band imaging
|
Other: Narrow band imaging
Colonoscopy with new narrow band imaging
|
- Detection rate of proximal serrated polyp [ Time Frame: During colonoscopy ]No. of patients with proximal serrated polyps
- Missed rate for proximal serrated polyps [ Time Frame: During colonoscopy ]Missing rate for proximal serrated polyps
- Adenoma detection rate [ Time Frame: during colonoscopy ]No. of patients with adenoma detected

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Ages Eligible for Study: | 40 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Probability Sample |
Inclusion Criteria:
- All patients scheduled to have colonoscopy
Exclusion Criteria:
- History of Crohn's or ulcerative colitis
- Surveillance for known polyposis syndrome (FAP or HNPCC)
- Previous colonic resection (except appendectomy)
- Refused consent
- Deranged coagulation profile that preclude polypectomy

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01725321
China | |
Queen Mary Hospital | |
Hong Kong, China |
Principal Investigator: | Wai Keung Leung, MD | The University of Hong Kong |
Responsible Party: | LEUNG Wai Keung, Clinical Professor, The University of Hong Kong |
ClinicalTrials.gov Identifier: | NCT01725321 History of Changes |
Other Study ID Numbers: |
NBI_1 |
First Posted: | November 12, 2012 Key Record Dates |
Last Update Posted: | May 29, 2015 |
Last Verified: | May 2015 |
Keywords provided by LEUNG Wai Keung, The University of Hong Kong:
Colonoscopy colonic adenoma serrated polyps |
Additional relevant MeSH terms:
Colonic Neoplasms Colorectal Neoplasms Intestinal Neoplasms Gastrointestinal Neoplasms Digestive System Neoplasms Neoplasms by Site |
Neoplasms Digestive System Diseases Gastrointestinal Diseases Colonic Diseases Intestinal Diseases |