Anti-Mullerian Hormone Levels Before and After an Open Myomectomy

This study has suspended participant recruitment.
(It has been put on hold for the moment due to logistic problems)
Information provided by (Responsible Party):
OVO R & D Identifier:
First received: November 5, 2012
Last updated: October 13, 2015
Last verified: October 2015

Anti-Mullerian hormone (AMH) is a marker for ovarian reserve. It is well known that ovarian surgery for endometriosis lowers Anti-Mullerian hormone, but little is known for other surgeries. We seek to investigate the hormone variations before and after an open myomectomy.

Hypothesis: Anti-Mullerian hormone levels drop following surgery but return to normal levels in a few months

Anti-Mullerian Hormone

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Anti-Mullerian Hormone Levels Variations Following an Open Myomectomy

Resource links provided by NLM:

Further study details as provided by OVO R & D:

Primary Outcome Measures:
  • Anti-Mullerian Hormone levels variation [ Time Frame: 6 months ] [ Designated as safety issue: No ]
    Anti-Mullerian Hormone levels before and 6 months after surgery

Biospecimen Retention:   Samples Without DNA
Blood samples collected to measure Anti-Mullerian hormone levels

Estimated Enrollment: 21
Study Start Date: March 2012
Estimated Primary Completion Date: March 2016 (Final data collection date for primary outcome measure)
Open myomectomy
All patients belong to the same group Description includes the surgical technique


Ages Eligible for Study:   18 Years to 42 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Women 18 to 42 tears old Indication for myomectomy by laparotomy

Inclusion Criteria:

  • 18 to 42 years old
  • Requiring open myomectomy for any indication

Exclusion Criteria:

  • Incapable of informed consent
  • Use of hormonal contraception or Gonadotropin-releasing hormone agonists in the past 3 months
  • Woman over 42 years old
  • Post-menopause women
  • Positive B-human chorionic gonadotropin the day of surgery
  • Ovarian surgery (at the same time)
  • Pre-operative AMH below 0.3 ng/mL
  Contacts and Locations
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Please refer to this study by its identifier: NCT01723085

Canada, Quebec
Hopital Saint-Luc
Montreal, Quebec, Canada, H2X 3J4
Sponsors and Collaborators
Principal Investigator: Eric Himaya, MD Centre Hospitalier de l'Université de Montréal
  More Information

No publications provided

Responsible Party: OVO R & D Identifier: NCT01723085     History of Changes
Other Study ID Numbers: AMH
Study First Received: November 5, 2012
Last Updated: October 13, 2015
Health Authority: Canada: Ethics Review Committee

Keywords provided by OVO R & D:
Anti-Mullerian hormone
Laparotomy processed this record on November 27, 2015