Genetic, Brain Structure, and Environmental Effects on ADHD
- Attention deficit hyperactivity disorder (ADHD) is one of the most common and inheritable of all neuropsychiatric disorders. It causes problems with attention and impulse control. However, the genetic component of ADHD has not been fully studied, including how genes interact with the environment. Researchers want to study children and adults who have ADHD. They will look at how genetic, brain structure, and environmental factors affect ADHD in children and adults.
- To study genetic, brain structure, and environmental factors in ADHD in children and adults.
- Individuals at least 3 years of age who have ADHD.
- Participants will be screened with a physical exam and medical history.
- Participants will be interviewed about their ADHD. They will also complete behavior and psychological tests. Parents or guardians will complete the tests along with participants under 18 years of age.
- Participants will provide saliva or blood samples.
- Participants will also have imaging studies of the brain.
- Participants under 25 years of age will return once a year to repeat the tests. Those over 25 years of age will have only the one set of tests. Those who are starting stimulant drugs and who are receiving behavioral treatment for the first time will also have another set of tests 12 weeks after the start of treatment.
|Attention Deficit Disorder With Hyperactivity|
|Study Design:||Time Perspective: Other|
|Official Title:||The Neurobehavioral, Environmental and Genetic Factors Impacting the Clinical Course of Attention Deficit Hyperactivity Disorder|
|Study Start Date:||September 7, 2012|
This study aims to provide novel phenotypes for genomic studies into Attention- Deficit Hyperactivity Disorder (ADHD), one of the most common and heritable of all neuropsychiatric disorders. It proposes to split the disorder into neurobiologically more meaningful entities by delineating subgroups based on neurobehavioral profiles. It will also explore factors that impact clinical course, focusing on the neural effects of treatment and the role of the child s social environment.
POPULATION AND DESIGN:
Using a prospective longitudinal design, a group of children and adolescents with ADHD will be followed. Additionally, families that have several members affected by ADHD will be recruited.
The study will link the onset and clinical course of ADHD with genotype, brain structure and function, behavior and the child s social environment.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01721720
|Contact: Wendy S Sharp, L.C.S.W.||(301) firstname.lastname@example.org|
|Contact: Wallace P Shaw, M.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Wallace P Shaw, M.D.||National Human Genome Research Institute (NHGRI)|