Satiety Effects on the Neural Valuation of Food

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01721187
Recruitment Status : Completed
First Posted : November 5, 2012
Last Update Posted : August 5, 2015
Singapore Institute for Clinical Sciences
Information provided by (Responsible Party):
MChee, Duke-NUS Graduate Medical School

Brief Summary:
Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Condition or disease
Fasting Fed

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety
Study Start Date : October 2012
Actual Primary Completion Date : December 2013
Actual Study Completion Date : July 2014

Low disinhibition
fMRI during fed and fasted states
High disinhibition
fMRI during fed and fasted states

Primary Outcome Measures :
  1. fMRI - Willingness to Pay task (BDM auction) [ Time Frame: Fed and fasted visits (Wks 1 & 2) ]
    A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.

  2. fMRI - Monetary and Food Incentive Delay task [ Time Frame: Fed and fasted visits (Wks 1 & 2) ]
    A measurement of neural response to anticipating and receiving money and food rewards.

Biospecimen Retention:   None Retained

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Ages Eligible for Study:   21 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample

Inclusion Criteria:

  • Chinese ethnicity
  • 21 to 45 years old
  • English as first language
  • Right-handed
  • Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
  • Weigh less than 100kg with an abdominal circumference of less than 120cm
  • Non-smoker, or only smoke occasionally (less than 5 sticks a week)
  • Consume less than 2 units (200 mg) of caffeine a day
  • Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
  • Habitually sleep before 1am and wake before 9am

Exclusion Criteria:

  • On a restrictive diet (e.g., vegetarian/vegan diet)
  • History of food allergies
  • History of psychiatric or neurological disorders
  • History of chronic medical illness
  • Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
  • Shift worker
  • Claustrophobic
  • High astigmatism (high = >2.00 diopters)
  • Colour-blind

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01721187

Centre for Cognitive Neuroscience scanner suite
Singapore, Singapore, 169611
Sponsors and Collaborators
Duke-NUS Graduate Medical School
Singapore Institute for Clinical Sciences
Principal Investigator: Michael WL Chee, MBBS Duke-NUS Graduate Medical School

Responsible Party: MChee, Professor, Duke-NUS Graduate Medical School Identifier: NCT01721187     History of Changes
Other Study ID Numbers: VOFIO3G
First Posted: November 5, 2012    Key Record Dates
Last Update Posted: August 5, 2015
Last Verified: August 2015

Keywords provided by MChee, Duke-NUS Graduate Medical School:
Willingness to Pay
Incentive Delay
Dietary Disinhibition