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Satiety Effects on the Neural Valuation of Food

This study has been completed.
Singapore Institute for Clinical Sciences
Information provided by (Responsible Party):
MChee, Duke-NUS Graduate Medical School Identifier:
First received: October 23, 2012
Last updated: August 4, 2015
Last verified: August 2015
Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.


Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Functional Magnetic Resonance Imaging Study of the Valuation of Food as a Function of Satiety

Further study details as provided by Duke-NUS Graduate Medical School:

Primary Outcome Measures:
  • fMRI - Willingness to Pay task (BDM auction) [ Time Frame: Fed and fasted visits (Wks 1 & 2) ]
    A measurement of how much participants are willing to pay for foods and non-foods, as an assay for subjective value of goods.

  • fMRI - Monetary and Food Incentive Delay task [ Time Frame: Fed and fasted visits (Wks 1 & 2) ]
    A measurement of neural response to anticipating and receiving money and food rewards.

Biospecimen Retention:   None Retained

Enrollment: 60
Study Start Date: October 2012
Study Completion Date: July 2014
Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Low disinhibition
fMRI during fed and fasted states
High disinhibition
fMRI during fed and fasted states


Ages Eligible for Study:   21 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Community sample

Inclusion Criteria:

  • Chinese ethnicity
  • 21 to 45 years old
  • English as first language
  • Right-handed
  • Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
  • Weigh less than 100kg with an abdominal circumference of less than 120cm
  • Non-smoker, or only smoke occasionally (less than 5 sticks a week)
  • Consume less than 2 units (200 mg) of caffeine a day
  • Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
  • Habitually sleep before 1am and wake before 9am

Exclusion Criteria:

  • On a restrictive diet (e.g., vegetarian/vegan diet)
  • History of food allergies
  • History of psychiatric or neurological disorders
  • History of chronic medical illness
  • Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
  • Shift worker
  • Claustrophobic
  • High astigmatism (high = >2.00 diopters)
  • Colour-blind
  Contacts and Locations
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Please refer to this study by its identifier: NCT01721187

Centre for Cognitive Neuroscience scanner suite
Singapore, Singapore, 169611
Sponsors and Collaborators
Duke-NUS Graduate Medical School
Singapore Institute for Clinical Sciences
Principal Investigator: Michael WL Chee, MBBS Duke-NUS Graduate Medical School
  More Information

Responsible Party: MChee, Professor, Duke-NUS Graduate Medical School Identifier: NCT01721187     History of Changes
Other Study ID Numbers: VOFIO3G
Study First Received: October 23, 2012
Last Updated: August 4, 2015

Keywords provided by Duke-NUS Graduate Medical School:
Willingness to Pay
Incentive Delay
Dietary Disinhibition processed this record on May 25, 2017