Effect of Beverages Containing Different Doses of Alginate Fibers on Appetite, Energy Intake and Glycemia (ALSAT)
|ClinicalTrials.gov Identifier: NCT01720784|
Recruitment Status : Completed
First Posted : November 2, 2012
Last Update Posted : September 3, 2014
Studies report that dietary fiber intake is inversely correlated with body weight gain. Previously, we have shown alginate fiber supplementation increases weight loss, which we ascribe to its satiating effct.Alginate is a major plant dietary fiber in brown seaweed. One property of importance to appetite is the ability of alginate to gel in the acidic environment of the stomach. We hypothesize that the alginate will decrease the feeling of hunger and lower food consumption compared to control.
Here we test three different beverages in a double-blinded crossover design, in which 24 participants will be randomly assigned to the sequence of the test days separated by at least 5 days.
On each test day appetite sensation as well as blood glucose and insulin will be measured over 4h after intake of the test product. Hereafter, an ad libitum meal consisting of Pasta Bolognese will be served, and energy intake calculated. The participants will also rate gastrointestinal confort.
|Condition or disease||Intervention/treatment||Phase|
|Obesity||Dietary Supplement: Alginate dietary fiber Dietary Supplement: Placebo||Not Applicable|
Three different iso-caloric beverages will be tested in a double-blinded crossover design, in which 24 participants will be randomly assigned to the sequence of the test days separated by at least 5 days. Prior to the test days, the participants will follow a standardized fasting procedure: abstention from alcohol hard physical activity for 24 h; furthermore, consumption of the same evening meal no later than 8 pm on the night before all meal tests, after which time point they should be fasting. They are allowed 500 mL of water between 8 pm and the morning of the test days.
On each test day, the participants will meet at the department in a fasting state. After voiding they will be weighed, and a venflon catheter will be inserted in the antecubital vein, allowing repeated blood sampling throughout the test day. Baseline measurements of blood pressure, blood samples, and visual analogue scales (VAS) scores will be conducted at time point of -15 min. A second baseline blood sample will be drawn at time point 0, immediately after which the participants will consume the preload beverage (time point 0) with a 10 min time limit for consumption. After consumption of the preload beverage, blood samples will be taken and VAS scores completed at time points 15 and 30 min, and hereafter the he standardized breakfast will be served for which 15 minutes is allowed (time point 30 min). After the participants have finished the breakfast, blood samples will be drawn and VAS scores completed at time points 45, 60, 90, 120, 180, 210 and 240 min.
Hereafter, an ad libitum meal consisting of Pasta Bolognese will be served, and energy intake calculated, and the final VAS score will be completed at time point 270 min after the participants have finished their lunch. Before leaving, the participants will fill in a questionnaire related to gastrointestinal adverse events (AE).
As a pilot study, the first 6 participants to finish the study will be invited to participate in a fourth test day, on which capsules containing alginate fibers will be administered together with the placebo beverage. This fourth test day is not included in the randomization and will not be blinded for the participants.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Effect of Beverages Containing Different Doses of Alginate Fibers on Appetite, Energy Intake and Glycemia|
|Study Start Date :||October 2012|
|Actual Primary Completion Date :||March 2013|
|Actual Study Completion Date :||July 2013|
|Placebo Comparator: Placebo||Dietary Supplement: Placebo|
|Experimental: Low dose (1.5 g DF)||Dietary Supplement: Alginate dietary fiber|
|Experimental: High dose (2.25 gDF)||Dietary Supplement: Alginate dietary fiber|
- Subjective appetite ratings including derivative measures [ Time Frame: Assessed 12 times over a 4hour period after each of three test meals served at least 5 days apart ]
- Ad libitum food intake at the subsequent meal [ Time Frame: Assessed after 4 hours after each of three test meals served at least 5 days apart ]
- Glucose and insulin response including derivative measures [ Time Frame: Assessed 12 times over a 4hour period after each of three test meals served at least 5 days apart ]
- Ratings of gastrointestinal discomfort during 24 hours following the test meals [ Time Frame: Assessed4 times over a 24 hour period after each of three test meals served at least 5 days apart ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01720784
|Department of Nutrition, Exercise and Sports, University of Copenhagen|
|Frederiksberg C, Denmark, 1958|