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Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository (PPS)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01720472
Recruitment Status : Completed
First Posted : November 2, 2012
Last Update Posted : January 31, 2019
Sponsor:
Information provided by (Responsible Party):
Duke University

Brief Summary:
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Condition or disease Intervention/treatment
Aging Physical Functioning Cognitive Functioning Fitness Genetic: Biomarker studies

Detailed Description:
The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.

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Study Type : Observational [Patient Registry]
Actual Enrollment : 1000 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 2 Years
Official Title: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository
Study Start Date : May 2012
Actual Primary Completion Date : August 28, 2018
Actual Study Completion Date : August 28, 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Health Checkup

Group/Cohort Intervention/treatment
Community, Physical Performance Genetic: Biomarker studies



Primary Outcome Measures :
  1. Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository [ Time Frame: Upto 2 years or 24 months ]
    Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.


Biospecimen Retention:   Samples With DNA
Serum and plasma samples collected from MURDOCK Study enrollment visit and two year follow up Physical Performance visit.


Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The study population will include 1,000 participants ages 30 and older living in Cabarrus County and/or the city of Kannapolis, or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina.
Criteria

Inclusion Criteria:

  • A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
  • Age 30 or older

Exclusion Criteria:

  • Female that is currently pregnant
  • Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
  • Participant that requires consent by a legally authorized representative
  • Participant that cannot walk 30ft without human assistance

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01720472


Locations
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United States, North Carolina
Bethesda Health Center
Charlotte, North Carolina, United States, 28262
McGill Family Medicine
Concord, North Carolina, United States, 28025
Carolinas Medical Center NorthEast Medical Arts Building
Concord, North Carolina, United States, 28205
Ada Jenkins Center
Davidson, North Carolina, United States, 28036
Harrisburg Sleep Center
Harrisburg, North Carolina, United States, 28075
Lake Norman Community Health Clinic
Huntersville, North Carolina, United States, 28078
Sponsors and Collaborators
Duke University
Investigators
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Principal Investigator: Miriam C Morey, Ph.D. Duke University

Additional Information:
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Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT01720472     History of Changes
Other Study ID Numbers: Pro00036608
First Posted: November 2, 2012    Key Record Dates
Last Update Posted: January 31, 2019
Last Verified: January 2019

Keywords provided by Duke University:
Aging
Healthy Aging
Physical Performance
Physical Functioning
Cognitive Functioning
Fitness
Physical Activity