Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository (PPS)

This study is currently recruiting participants. (see Contacts and Locations)
Verified January 2016 by Duke University
Sponsor:
Information provided by (Responsible Party):
Duke University
ClinicalTrials.gov Identifier:
NCT01720472
First received: October 31, 2012
Last updated: January 19, 2016
Last verified: January 2016
  Purpose
The purpose of this study is to use the MURDOCK Horizon 1.5 infrastructure (Duke Instutional Review Board Pro00011196) to specifically target and enroll 1,000 participants across age groups and other demographic categories in order to develop a diverse cohort with specific physical and cognitive performance data paired with biological samples.

Condition Intervention
Aging
Physical Functioning
Cognitive Functioning
Fitness
Genetic: Biomarker studies

Study Type: Observational [Patient Registry]
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 2 Years
Official Title: Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository

Resource links provided by NLM:


Further study details as provided by Duke University:

Primary Outcome Measures:
  • Implementing a Physical and Cognitive Performance Assessment Cohort in the MURDOCK Study Community Registry and Biorepository [ Time Frame: Upto 2 years or 24 months ] [ Designated as safety issue: No ]
    Factors associated with physical function and physical activity and change in physical activity and function over two-year follow-up.


Biospecimen Retention:   Samples With DNA
Serum and plasma samples collected from MURDOCK Study enrollment visit and two year follow up Physical Performance visit.

Estimated Enrollment: 1000
Study Start Date: May 2012
Estimated Study Completion Date: December 2017
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Community, Physical Performance Genetic: Biomarker studies

Detailed Description:
The MURDOCK Study, proposes this Horizon 2 study to collect a brief physical and cognitive performance assessment from 1,000 MURDOCK Registry participants. Blood sample aliquots will also be obtained. These physical and cognitive performance data, paired with -omics data from plasma and serum sample analyses, offer promise in the discovery of biomarkers for functional decline. This research will provide an important basis for our understanding of the physical, lifestyle, and genetic factors which, over the lifespan, contribute to changes in physical and cognitive capabilities as we age.
  Eligibility

Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
The study population will include 1,000 participants ages 30 and older living in Cabarrus County and/or the city of Kannapolis, or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina.
Criteria

Inclusion Criteria:

  • A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) or certain portions of Rowan, Mecklenburg, or Stanly counties in North Carolina for 6 or more months of the year.
  • Age 30 or older

Exclusion Criteria:

  • Female that is currently pregnant
  • Having had a heart attack, angina, congestive heart failure, or fluid in the lungs within the past 6 months
  • Participant that requires consent by a legally authorized representative
  • Participant that cannot walk 30ft without human assistance
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01720472

Contacts
Contact: Christy Flynn 704-250-5854 christy.flynn@duke.edu
Contact: Leah B Bouk 704-250-5859 leah.bouk@dm.duke.edu

Locations
United States, North Carolina
Bethesda Health Center Recruiting
Charlotte, North Carolina, United States, 28262
McGill Family Medicine Recruiting
Concord, North Carolina, United States, 28025
Carolinas Medical Center NorthEast Medical Arts Building Recruiting
Concord, North Carolina, United States, 28205
Ada Jenkins Center Recruiting
Davidson, North Carolina, United States, 28036
Harrisburg Sleep Center Recruiting
Harrisburg, North Carolina, United States, 28075
Lake Norman Community Health Clinic Recruiting
Huntersville, North Carolina, United States, 28078
Sponsors and Collaborators
Duke University
Investigators
Principal Investigator: Miriam C Morey, Ph.D. Duke University
  More Information

Additional Information:
Responsible Party: Duke University
ClinicalTrials.gov Identifier: NCT01720472     History of Changes
Other Study ID Numbers: Pro00036608 
Study First Received: October 31, 2012
Last Updated: January 19, 2016
Health Authority: United States: Institutional Review Board

Keywords provided by Duke University:
Aging
Healthy Aging
Physical Performance
Physical Functioning
Cognitive Functioning
Fitness
Physical Activity

ClinicalTrials.gov processed this record on July 21, 2016