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fMRI of Stress in Obesity

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
Yale University Identifier:
First received: October 29, 2012
Last updated: April 24, 2017
Last verified: December 2016
To examine the influence of obesity on brain activation during food cue, stress, and neutral relaxing conditions


Study Type: Observational
Study Design: Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Functional Magnetic Resonance Imaging of Stress in Obesity

Further study details as provided by Yale University:

Primary Outcome Measures:
  • No outcome measures for this study, this is an imaging study only [ Time Frame: Upon study completion ]

Estimated Enrollment: 60
Study Start Date: May 2008
Estimated Study Completion Date: May 2018
Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Subjects deemed to be medically healthy
Subjects deemed to be medically obese

Detailed Description:
Subjects will participate in an fMRI session to examine changes in frontal and limbic brain regions with food cues, stress and neutral/relaxing imagery

Ages Eligible for Study:   18 Years to 50 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
30 obese subjects and 30 matched healthy controls will be recruited for this study.

Inclusion Criteria:

  1. Between ages 18-50 years old.
  2. Able to read and write.
  3. negative urine toxicology screens during intake appointments indicating no history of current or past dependence on alcohol or illicit drug use.
  4. WOMEN: have a regular menstrual cycle.
  5. BMI: 30 < BMI < 35 for obese subjects (upper limit of 35 selected given our experience with heavier individuals fitting comfortably in the fMRI scanner) and 18.5 < BMI <25 for normal weight subjects (Institute, 2006)

Exclusion Criteria:

  1. any major neurological illness or injury and any current or prior clinically significant mental health (including PTSD) or substance use disorder (with exception of nicotine dependence) as determined by SCID interview;
  2. Regular use of any psychoactive drugs including anxiolytics and antidepressants.
  3. Any significant current medical condition such as neurological, cardiovascular, endocrine, renal, liver, thyroid pathology; subjects on medications for any medical condition will be excluded.
  4. Any subjects with foreign ferromagnetic metal objects in their body or other MR contraindications will be excluded including subjects who work as welders.
  5. Women on oral contraceptives, peri- and post-menopausal women, and pregnant or lactating women (as alterations in stress response are associated with these states).
  Contacts and Locations
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Please refer to this study by its identifier: NCT01719484

United States, Connecticut
Yale University School of Medicine
New Haven, Connecticut, United States, 06519
Sponsors and Collaborators
Yale University
Principal Investigator: Marc N Potenza, MD, PhD Yale University
  More Information

Responsible Party: Yale University Identifier: NCT01719484     History of Changes
Other Study ID Numbers: 0805003899
Study First Received: October 29, 2012
Last Updated: April 24, 2017

Additional relevant MeSH terms:
Nutrition Disorders
Body Weight
Signs and Symptoms processed this record on April 28, 2017