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Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath Condensate

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ClinicalTrials.gov Identifier: NCT01719393
Recruitment Status : Unknown
Verified October 2012 by National Taiwan University Hospital.
Recruitment status was:  Not yet recruiting
First Posted : November 1, 2012
Last Update Posted : November 1, 2012
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
Our hypothesis is that radial arterial pulse may reflect the severity and airway function in asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery in adult asthmatics, and evaluate its correlation with airy inflammation an lung funtion in asthmatics.

Condition or disease
Pulse Spectrum Analysis Pulmonary Function FeNO Metabolites

Detailed Description:
The microcirculation is directly involved in the cellular matabolism and homeostasis. Our hypothesis is that radial arterial pulse spectrum may reflect the airway condition in asthmatics. The aims of this study are to investigate the pulse spectrim of the radial artery in adult asthmatics, and evaluate its correlation with lung function, asthma control status,exhaled nitric oxide, and metabolites in the exhaed breath condensates.

Study Type : Observational
Estimated Enrollment : 100 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Pulse Spectrum Analysis in Adult Asthmatics: Correlation With Lung Function, Asthma Control Exhaled Nitric Oxide and Metabolites in Exhaled Breath
Study Start Date : November 2012
Estimated Primary Completion Date : November 2013
Estimated Study Completion Date : December 2013

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Asthma
U.S. FDA Resources




Primary Outcome Measures :
  1. Pulse spectral analysis [ Time Frame: one year ]

Biospecimen Retention:   Samples Without DNA
Exhaled brath condensate


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Asthma paitients
Criteria

Inclusion Criteria:

  • Meet the diagnostic criteria of GINA guideline asthma patients

Exclusion Criteria:

  • Cancer or immune impaired patients;
  • pack-year smoking> 5;
  • long-term ventilator-dependent patients
  • Control group: 30 age matched healthy controls

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01719393


Contacts
Contact: Ping-Hung Kuo 886-2-23123456 ext 63075 kph712@ntuh.gov.tw

Locations
Taiwan
National Taiwan University Hospital Not yet recruiting
Taipei, Taiwan
Contact: Ping-Hung Kuo    886-2-23123456 ext 63075    kph712@ntuh.gov.tw   
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Principal Investigator: Ping-Hung Kuo National Taiwan University Hospital

Responsible Party: National Taiwan University Hospital, M.D.
ClinicalTrials.gov Identifier: NCT01719393     History of Changes
Other Study ID Numbers: 201207062RIC
First Posted: November 1, 2012    Key Record Dates
Last Update Posted: November 1, 2012
Last Verified: October 2012

Keywords provided by National Taiwan University Hospital:
Asthma
Pulse spectrum analysis
lung function
exhaled nitric oxide
metabolites
exhaled breath condensate

Additional relevant MeSH terms:
Nitric Oxide
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Antioxidants
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Gasotransmitters
Protective Agents