Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Metastatic colorectal cancer
Progression after at least one prior standard of care regimen or be intolerant to irinotecan-based regimens
Life expectancy ≥ 3 months
ECOG performance status ≤ 2
Symptomatic or untreated leptomeningeal disease
Symptomatic brain metastasis
Patients with clinically manifested diabetes
Acute or chronic pancreatitis
Clinically significant cardiac disease
Other protocol-defined inclusion/exclusion criteria may apply.