Genetic Basis of Mitral Valve Prolapse (MVP)

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2015 by Massachusetts General Hospital
Leducq Foundation
Information provided by (Responsible Party):
Robert A. Levine, MD, Massachusetts General Hospital Identifier:
First received: October 30, 2012
Last updated: April 8, 2015
Last verified: April 2015
The investigators have successfully identified two novel genetic loci for MVP on chromosomes 11 and 13 and are searching for altered genes in these regions. This requires recruiting large families who may have MVP linked to these or other chromosomes; and obtaining DNA samples from 1,000-1,500 individually affected patients to study the relation between DNA markers throughout the genome and MVP. It is our expectation that the results of this study will lead to the discovery of gene(s) responsible for MVP. This will lead to improved understanding of the disease and, in turn, improved ability to treat and prevent progression in genetically susceptible individuals.

Mitral Valve Prolapse

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Genetic Basis of Mitral Valve Prolapse

Resource links provided by NLM:

Further study details as provided by Massachusetts General Hospital:

Primary Outcome Measures:
  • Discovery of the genetic basis of Mitral Valve Prolapse [ Time Frame: 5 years ] [ Designated as safety issue: No ]
    Genome-wide association

Biospecimen Retention:   Samples With DNA

Estimated Enrollment: 1500
Study Start Date: January 1999
Estimated Study Completion Date: December 2020
Estimated Primary Completion Date: December 2020 (Final data collection date for primary outcome measure)
Detailed Description:
This is a genome-wide association study.

Ages Eligible for Study:   18 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients referred for 2D echo for MVP

Inclusion Criteria:

  • Mitral valve prolapse

Exclusion Criteria:

  • Other mitral valve diseases
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01719211

Contact: Susan Slaugenhaupt, PhD 6176433217
Contact: Robert a levine, MD 6177241995

United States, Massachusetts
Mass General Hospital Recruiting
Boston, Massachusetts, United States, 02114
Sponsors and Collaborators
Massachusetts General Hospital
Leducq Foundation
Principal Investigator: robert a levine, MD Mass General Hospital
  More Information

Responsible Party: Robert A. Levine, MD, Cardiologist, Massachusetts General Hospital Identifier: NCT01719211     History of Changes
Other Study ID Numbers: 1999-p-007948 
Study First Received: October 30, 2012
Last Updated: April 8, 2015
Health Authority: United States: Institutional Review Board

Keywords provided by Massachusetts General Hospital:
MVP, mitral valve

Additional relevant MeSH terms:
Mitral Valve Prolapse
Cardiovascular Diseases
Heart Diseases
Heart Valve Diseases
Heart Valve Prolapse
Pathological Conditions, Anatomical processed this record on May 30, 2016