Periodontal Disease Treatment of a Physically Challenged Population (PDT)
Many physically handicapped patients at the dental department, Toronto Rehabilitation Institute(TRI) have considerable gingival inflammation and breath odour because of the inability to effectively handle a toothbrush. These patients have considerable periodontal disease. There is a concern that these pathogens may have a detrimental effect on wound healing in other areas of the body.
Hypothesis: Patients attending the dental department at TRI that are treated with the antibiotic-antifungal rinse containing metronidazole and nystatin will show substantial decrease in periodontal disease as measured by bleeding points and pocket depth when compared to the group that continues to use their regular oral hygiene methods (control group).
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment
|Official Title:||The Effect of an Antibiotic-antifungal Rinse on Periodontal Disease|
- Evidence of healing of periodontal tissues as shown by a reduction of bleeding [ Time Frame: two weeks ] [ Designated as safety issue: No ]Evidence of healing of periodontal tissues is assessed by measuring bleeding points and periodontal pocket depth using a dental probe.
|Study Start Date:||November 2013|
|Study Completion Date:||October 2014|
|Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Metronidazole-nystatin oral rinse, regular oral hygiene
Week 1: daily brushing with suction brush. Week two: daily brushing with a mixture of metronidazole-nystatin suspension.
|Drug: metronidazole-nystatin oral rinse|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01718912
|Toronto Rehabilitation Institute, Dental Department|
|Toronto, Ontario, Canada, M5G 2A2|