Prebiotics as a Means to Modulate Gut Fermentation, Metabolism, Appetite and Cognition
This study aims at investigating the impact of colonic fermentation of intrinsic indigestible carbohydrates in cereal whole kernels after three days consumption, on metabolic variables and cognition. The study is performed in healthy, normal to slightly over-weight test subjects.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
|Official Title:||Prebiotics as Means to Modulate Colonic Events, With the Purpose to Increase Beneficial Effects on Metabolism, Satiety and Cognition.|
- Area under the plasma concentration versus time curve (AUC) of the test meal [ Time Frame: Post-prandially after breakfast, 0-150 min ] [ Designated as safety issue: No ]The differences in AUC between different risk markers, assessed in plasma or serum,after intake of the test meal in comparison to the reference meal is measured. Example of variables measured are glucose, insulin, appetite hormones, inflammatory markers, markers of colonic fermentation.
- Cognitive performance [ Time Frame: Post-prandially after breakfast, 0-210 min ] [ Designated as safety issue: No ]The cognitive performance of the test subjects is measured to investigate work memory and specific attention.
- Subjective satiety [ Time Frame: post-prandially after breakfast, 0-150 min ] [ Designated as safety issue: No ]The subjective sensation of satiety, hunger and desire to eat is measured using a questionnaire.
|Study Start Date:||October 2010|
|Study Completion Date:||March 2013|
|Primary Completion Date:||March 2013 (Final data collection date for primary outcome measure)|
Experimental: indigestible carbohydrates
test meal: indigestible carbohydrates
|Other: test meal|
reference meal: no indigestible carbohydrates
|Other: reference meal|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01718431
|Applied Nutrition and Food Chemistry, Lund University|
|Lund, Sweden, SE-221 00|
|Principal Investigator:||Anne Nilsson, PhD||Lund University|