Prebiotics as a Means to Modulate Gut Fermentation, Metabolism, Appetite and Cognition
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|ClinicalTrials.gov Identifier: NCT01718431|
Recruitment Status : Completed
First Posted : October 31, 2012
Last Update Posted : May 8, 2013
|Condition or disease||Intervention/treatment||Phase|
|Metabolic Syndrome||Other: test meal Other: reference meal||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||40 participants|
|Intervention Model:||Crossover Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Prebiotics as Means to Modulate Colonic Events, With the Purpose to Increase Beneficial Effects on Metabolism, Satiety and Cognition.|
|Study Start Date :||October 2010|
|Actual Primary Completion Date :||March 2013|
|Actual Study Completion Date :||March 2013|
Experimental: indigestible carbohydrates
test meal: indigestible carbohydrates
Other: test meal
reference meal: no indigestible carbohydrates
Other: reference meal
- Area under the plasma concentration versus time curve (AUC) of the test meal [ Time Frame: Post-prandially after breakfast, 0-150 min ]The differences in AUC between different risk markers, assessed in plasma or serum,after intake of the test meal in comparison to the reference meal is measured. Example of variables measured are glucose, insulin, appetite hormones, inflammatory markers, markers of colonic fermentation.
- Cognitive performance [ Time Frame: Post-prandially after breakfast, 0-210 min ]The cognitive performance of the test subjects is measured to investigate work memory and specific attention.
- Subjective satiety [ Time Frame: post-prandially after breakfast, 0-150 min ]The subjective sensation of satiety, hunger and desire to eat is measured using a questionnaire.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01718431
|Applied Nutrition and Food Chemistry, Lund University|
|Lund, Sweden, SE-221 00|
|Principal Investigator:||Anne Nilsson, PhD||Lund University|