Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01718405
Recruitment Status : Unknown
Verified October 2012 by Hillel Yaffe Medical Center.
Recruitment status was:  Not yet recruiting
First Posted : October 31, 2012
Last Update Posted : October 31, 2012
Information provided by (Responsible Party):
Hillel Yaffe Medical Center

Brief Summary:
Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise. The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.

Condition or disease Intervention/treatment Phase
Executive Function Other: Cognitive function after exercise test Genetic: Blood sample analysis Not Applicable

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 150 participants
Intervention Model: Single Group Assignment
Primary Purpose: Basic Science
Study Start Date : November 2012
Estimated Primary Completion Date : November 2015
Estimated Study Completion Date : November 2017

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control. Cognitive function will be tested before and after each session.
Other: Cognitive function after exercise test
The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.
Genetic: Blood sample analysis
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.

Primary Outcome Measures :
  1. Cognitive Functioning After Exercise [ Time Frame: Five minutes ]
    Computerized battery of tests evaluating cognitive functioning

Other Outcome Measures:
  1. Genetic Variation Associated with Different Cognitive Functioning [ Time Frame: Two years ]
    Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.

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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Physical Education Students
  • Able to sign consent form

Exclusion Criteria:

  • Competitive athletes
  • Smokers
  • Neurologic or psychologic orders
  • Chronic diseases
  • Head Injuries
  • Hospitalization in the previous 3 months
  • Pregnant

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01718405

Contact: Sharon Tsuk, PhD 972-522-640642

Wingate Institute Not yet recruiting
Netanya, Israel
Principal Investigator: Raffael Carasso, MD         
Sub-Investigator: Sharon Tsuk, PhD         
Sponsors and Collaborators
Hillel Yaffe Medical Center

Responsible Party: Hillel Yaffe Medical Center Identifier: NCT01718405     History of Changes
Other Study ID Numbers: 0049
First Posted: October 31, 2012    Key Record Dates
Last Update Posted: October 31, 2012
Last Verified: October 2012