Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function
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|ClinicalTrials.gov Identifier: NCT01718405|
Recruitment Status : Unknown
Verified October 2012 by Hillel Yaffe Medical Center.
Recruitment status was: Not yet recruiting
First Posted : October 31, 2012
Last Update Posted : October 31, 2012
|Condition or disease||Intervention/treatment|
|Executive Function||Other: Cognitive function after exercise test Genetic: Blood sample analysis|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||150 participants|
|Intervention Model:||Single Group Assignment|
|Primary Purpose:||Basic Science|
|Study Start Date :||November 2012|
|Estimated Primary Completion Date :||November 2015|
|Estimated Study Completion Date :||November 2017|
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control. Cognitive function will be tested before and after each session.
Other: Cognitive function after exercise test
The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order. Before and after each session, the subject will take computerized cognitive tests.Genetic: Blood sample analysis
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.
- Cognitive Functioning After Exercise [ Time Frame: Five minutes ]Computerized battery of tests evaluating cognitive functioning
- Genetic Variation Associated with Different Cognitive Functioning [ Time Frame: Two years ]Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism. A mutation will be discriminated by digestion with specific restriction endonucleases.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01718405
|Contact: Sharon Tsuk, PhDemail@example.com|
|Wingate Institute||Not yet recruiting|
|Principal Investigator: Raffael Carasso, MD|
|Sub-Investigator: Sharon Tsuk, PhD|