The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With Acute Respiratory Distress Syndrome (ARDS) Managed on a Fluid Protocol
|ClinicalTrials.gov Identifier: NCT01714583|
Recruitment Status : Completed
First Posted : October 26, 2012
Last Update Posted : October 26, 2012
|Condition or disease|
|Acute Respiratory Distress Syndrome (ARDS)|
|Study Type :||Observational|
|Actual Enrollment :||367 participants|
|Official Title:||The Relationship Between Positive End Expiratory Pressure and Cardiac Index in Patients With ARDS Managed on a Fluid Protocol: A Secondary Analysis of a Prospective Trial|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||September 2012|
|Actual Study Completion Date :||September 2012|
Cohort of participants with positive end-expiratory pressure (PEEP) greater than or equal to 12cm.
Cohort of participants with positive end-expiratory pressure (PEEP) less than 12cm.
- Cardiac Index [ Time Frame: Cross sectional (i.e. at time Zero only) ]
The cardiac index is a cardiodynamic measure based on the cardiac output, which is the amount of blood the left ventricle ejects into the systemic circulation in one minute, measured in liters per minute (l/min). Cardiac output is indexed to a patient's body size by dividing by the body surface area to yield the cardiac index.
The cardiac index which is the outcome measure is assessed at the same time as the PEEP (which is the independent variable) is measured.
The study participants are NOT followed for any period of time. This is a cross-sectional study design. Both variables (Cardiac index and PEEP) are measured at the same time.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01714583
|United States, Connecticut|
|Yale University, School of Medicine, Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine|
|New Haven, Connecticut, United States, 06510|
|Principal Investigator:||Wassim H Fares, MD MSc||Yale University, School of Medicine, Department of Internal Medicine, Section of Pulmonary and Critical Care Medicine|