Nebulized Bronchodilatators and Cardiac Repolarization
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ClinicalTrials.gov Identifier: NCT01714401 |
Recruitment Status
: Unknown
Verified October 2012 by Radoslaw Owczuk, Medical University of Gdansk.
Recruitment status was: Recruiting
First Posted
: October 25, 2012
Last Update Posted
: October 25, 2012
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Influence of Nebulized Bronchodilatators on Selected Electrophysiological Parameters | Drug: ventolin 2.5mg Drug: Ventolin 5mg Drug: Atrovent 0.5mg | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 75 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Triple (Participant, Care Provider, Investigator) |
Official Title: | The Development of Procedures to Optimalize the Intensive Care Units Patients Clinical Condition. Evaluation of Influence of Nebulized Bronchodilatatory Drugs on Cardiac Repolarization |
Study Start Date : | March 2012 |
Estimated Primary Completion Date : | April 2013 |

Arm | Intervention/treatment |
---|---|
Active Comparator: Salbutamol 2,5 mg |
Drug: ventolin 2.5mg
20 min nebulization of 2.5 mg of salbutamol
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Active Comparator: Salbutamol 5mg |
Drug: Ventolin 5mg
20 min nebulization of 5 mg of salbutamol
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Active Comparator: Ipratropium 0.5 |
Drug: Atrovent 0.5mg
20 min nebulization of 0.5 mg of ipratropium bromide
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- Changes of electrophysiological parameters after nebulized bronchodilatator [ Time Frame: one hour ]

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Ages Eligible for Study: | 18 Years and older (Adult, Senior) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- the necessity of b2 adrenergics an m2 mimetics administration
Exclusion Criteria:
- patients with past medical history of ventricular arrhythmias ( ventricular tachycardia, ventricular fibril, Torsade de pointes)
- patients with persistent atrial fibrillation
- patients with abnormal plasma sodium, potassium, magnesium, and ionized calcium concentration

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01714401
Contact: Tomasz Jasinski, MD | 0048-058-349-32-82 | tjasinski@uck.gda.pl |
Poland | |
Medical University of Gdansk - Departament of Anesthesiolog and Intensive cCre | Recruiting |
Gdansk, Poland, 80-214 | |
Contact: Tomasz Jasinski, MD tjasinski@uck.gda.pl | |
Principal Investigator: Radoslaw Owczuk, Ph.D. | |
Sub-Investigator: Tomasz Jasinski, MD | |
Medical University of Gdańsk - Departament of Anesthesiology and Intensive Care | Recruiting |
Gdańsk, Poland, 80-214 | |
Principal Investigator: Radoslaw Owczuk, Ph.D. | |
Sub-Investigator: Tomasz Jasinski, MD |
Responsible Party: | Radoslaw Owczuk, associate professor, Medical University of Gdansk |
ClinicalTrials.gov Identifier: | NCT01714401 History of Changes |
Other Study ID Numbers: |
TJ-1 |
First Posted: | October 25, 2012 Key Record Dates |
Last Update Posted: | October 25, 2012 |
Last Verified: | October 2012 |
Additional relevant MeSH terms:
Albuterol Ipratropium Bronchodilator Agents Autonomic Agents Peripheral Nervous System Agents Physiological Effects of Drugs Anti-Asthmatic Agents Respiratory System Agents Tocolytic Agents |
Reproductive Control Agents Adrenergic beta-2 Receptor Agonists Adrenergic beta-Agonists Adrenergic Agonists Adrenergic Agents Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Cholinergic Antagonists Cholinergic Agents |