Study of Variables Related to the Discontinuation of Mechanical Ventilation in Patients With Head Injury (INDEXTBI)
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ClinicalTrials.gov Identifier: NCT01713010
Recruitment Status : Unknown
Verified October 2012 by Camila Marques Dias, Federal University of Uberlandia. Recruitment status was: Recruiting
First Posted : October 24, 2012
Last Update Posted : October 25, 2012
Federal University of Uberlandia
Information provided by (Responsible Party):
Camila Marques Dias, Federal University of Uberlandia
The purpose of this study is to evaluate physiological variables to the decision about the appropriate time to discontinuation of mechanical ventilation in patients with traumatic brain injury. It is expected that these variables are effective in predicting the outcome of weaning from mechanical ventilation.
Other: Predictive indexes of weaning from mechanical ventilation
The aim of this study is to evaluate the effectiveness of integrated pressure index of airway occlusion x index breathing fast and shallow (p 0.1 x f/VT) in predicting success and failure of weaning from mechanical ventilation in patients with traumatic brain injury.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients admitted to the intensive care unit with brain trauma in the process of weaning from mechanical ventilation.
Traumatic Brain Injury (TBI)
Patients using artificial airway (intubation and / or tracheostomy)
Recovery from the acute phase of the disease underlying
Ventilation mode pressure support (PSV), pressure support (PS) required to ensure a tidal volume (VT) = 6 to 8 ml / kg
Age over 18 years
Hemoglobin > 7 g/dL
Duration of mechanical ventilation longer than 24 hours
Body temperature < 38 degrees
pH ≥ 7.30
PaO2 ≥ 60 mmHg with FiO2 ≤ 0.4 and PEEP ≤ 8 cmH2O
Glasgow Coma Scale ≥ 8 or tracheostomized
Sedative agents minimum dosages to to maintain values of 2 or 3 on the Ramsay Scale
Admitted to the ICU with artificial airways held in other institutions
Surgery scheduled for the next 72 hours
Withdrawal of consent from parents at any stage of the research