Treatment of Acute Periprosthetic Total Hip Arthroplasty Infections
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ClinicalTrials.gov Identifier: NCT01712880
(The study was not feasible.)
The purpose of this study is to determine the success rate of two treatments for infection after total hip replacement: single stage arthroplasty exchange (your surgeon will take out your original implants and replace them with a complete new set) compared to irrigation and debridement with modular exchange (your surgeon will clean your implants with a surgical solution and take out the plastic liner and replace it with a new one - the rest of your hip implants will stay in place). The goal is to see if one is better than the other for the treatment of hip infection after a total hip replacement. A successful treatment means that you did not have to have another surgery on your hip for an infection-related reason.
Condition or disease
Periprosthetic Infection Total Hip Arthoplasty
Procedure: open debridement with modular exchangeProcedure: one stage exchange
The Treatment of the Acute Periprosthetic Hip Infection After Uncemented Total Hip Arthroplasty: A Randomized Study Comparing Open Debridement Component Retention (ODCR) With Modular Exchange Versus One Stage Exchange Arthroplasty
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Return to the OR for a drainage procedure within six weeks of index primary uncemented arthroplasty 1a) Exam findings within six weeks of index operation:
Drainage for more than 7 days
Wound appearance consistent with deep infection or hematoma
Persistent fever or evidence of bacteremia
All patients currently deemed appropriate for irrigation and debridement
- Rising inflammatory seromarkers
Aspiration with a positive culture
Previous history of periprosthetic infection
Patients not willing to consent for the proposed treatment