Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries
Acute changes in axial diffusivity will correlate with the severity of injury in patients that suffer an acute spinal cord injury.
Cervical Spinal Cord Injury
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Diffusion Tensor MRI to Assess Subacute Functional Outcomes in Patients With Acute Cervical Spinal Cord Injuries|
- Change in AISA score [ Time Frame: 24 months ] [ Designated as safety issue: No ]Patients will be followed for the duration of their hospital stay with clinical follow-up out to 2 years. ASIA scores will be correlated with admission DTI findings(Axial Diffusivity).
|Study Start Date:||January 2014|
|Estimated Study Completion Date:||June 2017|
|Estimated Primary Completion Date:||January 2016 (Final data collection date for primary outcome measure)|
Cervical spinal cord injury
Those patients with an acute cervical spinal cord injury evaluated with DTI MRI
Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury in SCI patients as seen in rodent models. We will test whether the quantitative decrease in axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional outcomes for patients with a SCI.
Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of the patient.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01712698
|Contact: Jeanine Wade, RTemail@example.com|
|Contact: Rory Murphy, MDfirstname.lastname@example.org|
|United States, Missouri|
|Washington University, School of Medicine||Recruiting|
|St. Louis, Missouri, United States, 63110|
|Contact: Jeanine Wade, RT 314-362-2940 email@example.com|
|Contact: Rory Murphy, MD 314-294-1654 firstname.lastname@example.org|
|Principal Investigator: Wilson Ray, MD|
|Sub-Investigator: Sheng-Kwei Song, PhD|
|Sub-Investigator: Rory Murphy, MD|