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Curcumin Bioavailability in Glioblastoma Patients

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ClinicalTrials.gov Identifier: NCT01712542
Recruitment Status : Completed
First Posted : October 23, 2012
Last Update Posted : June 4, 2013
Sponsor:
Information provided by (Responsible Party):
Stephan Dützmann, Johann Wolfgang Goethe University Hospitals

Brief Summary:
Measuring the bioavailability of orally administered curcumin in the tumors of glioblastoma patients.

Condition or disease Phase
Patient Harboring Glioblastoma That Will Undergo Surgery Early Phase 1

Study Type : Observational
Estimated Enrollment : 15 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Measurement of Intratumoral Concentration of the Nontoxic Natural Compound Curcumin in Glioblastoma Patients
Study Start Date : October 2012
Primary Completion Date : May 2013
Study Completion Date : May 2013

Resource links provided by the National Library of Medicine

U.S. FDA Resources




Primary Outcome Measures :
  1. Concentration of Curcumin in Glioblastoma [ Time Frame: At Tumor resection ]
    At the time of surgery


Biospecimen Retention:   Samples Without DNA
Tumor tissue


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients harboring Glioblastoma
Criteria

Inclusion Criteria:

  • Patients harboring Glioblastoma
  • Patient will undergo surgery

Exclusion Criteria:

  • BMI > 30
  • Liver and Kidney Function so compromised that medication is prescribed

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01712542


Locations
Germany
Department of Neurosurgery, Johann Wolfgang Goethe-University
Frankfurt, Hessen, Germany, 60528
Sponsors and Collaborators
Johann Wolfgang Goethe University Hospital
Investigators
Principal Investigator: Stephan Duetzmann Goethe University

Additional Information:
Publications:
Responsible Party: Stephan Dützmann, M.D., Johann Wolfgang Goethe University Hospitals
ClinicalTrials.gov Identifier: NCT01712542     History of Changes
Other Study ID Numbers: JohannWGUH_Curcumin-01
First Posted: October 23, 2012    Key Record Dates
Last Update Posted: June 4, 2013
Last Verified: June 2013

Additional relevant MeSH terms:
Glioblastoma
Astrocytoma
Glioma
Neoplasms, Neuroepithelial
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms
Neoplasms, Glandular and Epithelial
Neoplasms, Nerve Tissue
Curcumin
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Anti-Inflammatory Agents
Antirheumatic Agents
Antineoplastic Agents
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action