Neovascular Age-related Macular Degeneration (NVAMD)
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|ClinicalTrials.gov Identifier: NCT01712035|
Recruitment Status : Completed
First Posted : October 23, 2012
Last Update Posted : April 5, 2018
Age-related macular degeneration (AMD) is the leading cause of blindness in non-Hispanic white Americans. Neovascular AMD is an advanced form of macular degeneration that historically has accounted for the majority of vision loss related to AMD. The presence of choroidal neovascular membrane (CNV) formation is the hallmark feature of neovascular AMD. Choroidal neovascular membranes consist of buds of neovascular tissue and accompanying fibroblasts from the choroid perforating Bruch's membrane with extension either above or below the retinal pigment epithelium. These neovascular complexes are associated with hemorrhage, fluid exudation and fibrosis formation resulting in photoreceptor damage and vision loss. Treatment of neovascular AMD consists of injecting inhibitors of vascular endothelial growth factor (VEGF) into the vitreous cavity to interfere with proliferation of choroidal neovascularization and to reduce vascular permeability.
OCT is an imaging technology that can perform non-contact cross-sectional imaging of retinal and choroidal tissue structure in real time. It is analogous to ultrasound B-mode imaging, except that OCT measures the intensity of reflected light rather than acoustical waves.
This observational study will use OCT technology to study and compare the retinal and choroidal anatomy and blood flow in two groups of patients with neovascular AMD: treatment naïve group and active treatment group.
The purpose of this study is to assess the utility of OCT angiography in the evaluation of NVAMD.
|Condition or disease|
|Neovascular Age-related Macular Degeneration|
|Study Type :||Observational|
|Actual Enrollment :||44 participants|
|Official Title:||OCT Evaluation of Treated and Untreated Choroidal Neovascular Membranes in Age-Related Macular Degeneration|
|Actual Study Start Date :||October 2012|
|Actual Primary Completion Date :||December 5, 2017|
|Actual Study Completion Date :||December 5, 2017|
Patients with NVAMD who have received treatment with an anti-VEGF agent (Avastin, Lucentis, Macugen, or Eylea) 6 weeks prior enrollment visit
Individuals who have not received any treatment for neovascular AMD in the study eye
- Number of patients with NVAMD receiving treatment who also have changed retinal/choroidal anatomy and/or blood flow compared to treatment naive NVAMD patients [ Time Frame: 1 year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01712035
|United States, Oregon|
|Oregon Health & Science University|
|Portland, Oregon, United States, 97239|