Serum TNF-a in Comparison to Sequential Organ Failure Assessment (SOFA) Score Monitoring in Critically Ill Patients
|ClinicalTrials.gov Identifier: NCT01708772|
Recruitment Status : Completed
First Posted : October 17, 2012
Last Update Posted : June 7, 2013
|Condition or disease|
|Sepsis Critically Ill|
|Study Type :||Observational|
|Actual Enrollment :||90 participants|
|Observational Model:||Case Control|
|Official Title:||The Predictive Prognostic Values of Serum TNF-a in Comparison to SOFA Score Monitoring in Critically Ill Patients|
|Study Start Date :||November 2012|
|Actual Primary Completion Date :||December 2012|
|Actual Study Completion Date :||January 2013|
Forty five patients developed septic complication during ICU stay (sepsis group).
Forty five patients were critically ill without evidence of infectious organism (SIRS group).
- TNF-a determination using ELISA. [ Time Frame: Participants will be followed for the duration of ICU stay, At admission, 3rd, 5th and 7th day of ICU stay.Patients will be followed for at least 2 weeks. ]A serum level of TNF-a was determined by quantitative sandwich enzyme immunoassay (R&D Systems, Inc., Minneapolis, MN, USA) guided by to the manufacturer's instructions. The intensity of the color was measured at 490 nm.
- Evaluation of SOFA score: [ Time Frame: Participants will be followed for the duration of ICU stay, at admission, 3rd, 5th, and 7th day of ICU stay.Patients will be followed for at least 2 weeks. ]SOFA score is composed of scores of six organ systems (respiratory [R], cardiovascular [C], hepatic [H], coagulation [Co], renal [Re], and neurological [N]) graded from 0 to 4 according to the degree of dysfunction/ failure.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01708772
|Tanta, Algharbiya, Egypt, 35217|
|Principal Investigator:||Ayman A Yousef, MD||Assistant professor os Anesthesia and ICU, Faculty of Medicine, Tanta university|