The MURDOCK Study Registry and Biorepository Horizon 1.5 (MURDOCK)

Study Description

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Brief Summary:

The MURDOCK Study Community Registry and Biorepository (Horizon 1.5) aims to create a large-scale community registry and biorepository that can be used as a vehicle for future health services, epidemiologic, clinical trials and other omics-related research.

Condition or disease	Intervention/treatment
Chronic Disease; Healthy Volunteers	Genetic: Biomarker studies

Detailed Description:

The MURDOCK Study Community Registry and Biorepository's activities include enrolling approximately 50,000 participants who live in Cabarrus County and/or Kannapolis, North Carolina. Participants must consent to (1) use of the data provided by the participant through completion of the Participant Registry Questionnaire for epidemiologic population characterization, (2) annual contact to update their MURDOCK Horizon 1.5 database record, (3) release of their medical information, including but not limited to demographic information, problem lists, medications, social and family history, and results of laboratory and other testing modalities from pre-existing paper or electronic health records or electronic health records that may become available in the future, (4) provision of a blood and urine sample, and (5) contact up to four times/year to request participation in additional research studies.

Study Design

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Study Type :	Observational
Estimated Enrollment :	50000 participants
Observational Model:	Other
Time Perspective:	Prospective
Official Title:	Measurement to Understand Reclassification of Disease of Cabarrus/Kannapolis The MURDOCK Study Registry and Biorepository Horizon 1.5
Study Start Date :	February 2009
Estimated Primary Completion Date :	December 2020
Estimated Study Completion Date :	December 2020

Groups and Cohorts

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Group/Cohort	Intervention/treatment
community	Genetic: Biomarker studies

Outcome Measures

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Primary Outcome Measures :

1. The MURDOCK Study Registry and Biorepository Horizon 1.5 [ Time Frame: Upto 119 months ]
   To provide information for large-scale epidemiologic and clinical translational research and the research infrastructure to identify specific phenotypes and outcomes to improve medicine

Biospecimen Retention:   Samples With DNA

Blood, 25 mL (whole blood, plasma, serum, buffy coat, PAXgene); Urine, 36 mL

Eligibility Criteria

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Ages Eligible for Study:	18 Years and older (Adult, Senior)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

The Community Registry and Biorepository is designed to create a community registry and biorepository populated by approximately 50,000 residents of Cabarrus County and/or the city of Kannapolis in North Carolina.

Criteria

Inclusion Criteria:

1. A resident of Cabarrus County and/or the city of Kannapolis (and surrounding regions) for 6 or more months of the year
2. At least 18 years of age
3. Able to understand and give written informed consent, or have a legal guardian or caregiver present to give informed consent by proxy (assent from a participant between ages 12-18 will be obtained when their parent or legal guardian consents on their behalf).
4. Willing and able to participate in all 5 components of the registry and biorepository as described above in Section III

Exclusion Criteria:

1. There are no exclusions to participation if all inclusion criteria have been met.

Contacts and Locations

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Contacts

Contact: Leah Bouk	704-250-5856	leah.bouk@duke.edu
Contact: Perla Nunes	704-250-5858	perla.nunes@duke.edu

Locations

United States, North Carolina
Duke Translational Medicine Institute-MURDOCK Study	Recruiting
Kannapolis, North Carolina, United States, 28081
Contact: Leah Bouk 704-250-5861 leah.bouk@duke.edu
Contact: Perla Nunes 704-250-5858 perla.nunes@duke.edu
Principal Investigator: L. Kristin Newby, MD, MHS

Sponsors and Collaborators

Duke University

Investigators

Principal Investigator:	Kristin M Newby, MD	Duke University

More Information

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Study Description Study Design Groups and Cohorts Outcome Measures Eligibility Criteria Contacts and Locations More Information

Additional Information:

MURDOCK Study website 

Publications:

Tenenbaum JD, Christian V, Cornish MA, Dolor RJ, Dunham AA, Ginsburg GS, Kraus VB, McHutchison JG, Nahm ML, Newby LK, Svetkey LP, Udayakumar K, Califf RM. The MURDOCK Study: a long-term initiative for disease reclassification through advanced biomarker discovery and integration with electronic health records. Am J Transl Res. 2012;4(3):291-301. Epub 2012 Jul 23.

Responsible Party:	Duke University
ClinicalTrials.gov Identifier:	NCT01708408 History of Changes
Other Study ID Numbers:	Pro00011196
First Posted:	October 17, 2012
Last Update Posted:	February 12, 2018
Last Verified:	February 2018

Keywords provided by Duke University:

biorepository; biobank; registry; community; biospecimens; volunteers	chronic disease; longitudinal; blood; electronic health records; follow-up

Additional relevant MeSH terms:

Chronic Disease; Disease Attributes; Pathologic Processes