Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series (AMPOCD)
|ClinicalTrials.gov Identifier: NCT01708226|
Recruitment Status : Completed
First Posted : October 16, 2012
Last Update Posted : January 16, 2017
Pediatric Obsessive Compulsive Disorder (OCD) is a chronic, impairing condition that accrues significant concurrent and long-term risk to affected youth. Although empirically supported psychosocial and pharmacological treatments for OCD exist, many children and their families are not able to adequately access these treatments or derive only partial benefit from them. Such findings highlight the importance of developing more effective treatment options which have the potential to be widely accessible to OCD youth.
The investigators are proposing to test a computerized attention modification program, AMP, in six youth with OCD in an open case series to gather information regarding protocol acceptability, feasibility and preliminary efficacy. This phase includes the development and refinement of stimuli selection procedures, behavior avoidance task, EEG protocol, and AMP parameters for use with children.
Following ascertainment of study eligibility, participants will undergo a baseline assessment consisting of a clinical interview, neurocognitive assessments, EEG, attention bias assessment, and self report questionnaires. Study participants will then receive 12 sessions of AMP treatment over the course of three weeks. All youngsters and their families will be reassessed at treatment endpoint (week 4). Participation will take a total of about 24 hours over the course of six weeks. Participants who are treatment responders may be asked to return approximately 3 months after completing treatment for a follow-up assessment.
Preliminary hypotheses: 1) AMP will be acceptable to youth and families and feasible to administer; 2) Youth receiving AMP will demonstrate decreases in threat bias and OCD symptom severity.
|Condition or disease||Intervention/treatment||Phase|
|Obsessive Compulsive Disorder||Behavioral: Attention Modification Program||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||6 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series|
|Study Start Date :||November 2012|
|Actual Primary Completion Date :||November 2013|
|Actual Study Completion Date :||August 2016|
Experimental: Attention Modification Program
Attention Modification Program
Behavioral: Attention Modification Program
Computer-based attention training treatment designed to directly but implicitly modify biased attention patterns in anxious patients in service of symptom relief.
Other Name: AMP
- Children's Yale-Brown Obsessive Compulsive Scale Change From Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]
- Clinical Global Impression-Severity (CGI-S) and Improvement (CGI-I) Scales Change From Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]
- Attention Bias Assessment Change from Pre-Treatment to Post-Treatment [ Time Frame: pre-treatment (week 0) and post-treatment (week 5) ]Computerized assessment of attention bias
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01708226
|United States, California|
|University of California Los Angeles|
|Los Angeles, California, United States, 90024|
|Principal Investigator:||Susanna Chang, PhD||University of California, Los Angeles|
|Principal Investigator:||John Piacentini, PhD||University of California, Los Angeles|
|Principal Investigator:||James McCraken, MD||University of California, Los Angeles|