Effects of Stress on Glucose Tolerance During Pregnancy
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|ClinicalTrials.gov Identifier: NCT01707784|
Recruitment Status : Unknown
Verified May 2016 by Jardena Puder, University of Lausanne Hospitals.
Recruitment status was: Active, not recruiting
First Posted : October 16, 2012
Last Update Posted : May 12, 2016
The objective of the study is to investigate the effect of stress on glucose tolerance during pregnancy.
The main objectives of the study are to investigate if various measures of stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations) differ between pregnant women with and without gestational diabetes during the end of the second/beginning of the third trimester when presenting for their routine glucose tolerance testing.
Secondary objectives are the link between these different stress measures and the routinely measured fasting and stimulated glucose levels during the oral glucose tolerance test.
|Condition or disease|
|Pregnancy Stress Gestational Diabetes|
Hypotheses in this study, 3 primary hypotheses will be tested.
- Women with gestational diabetes have more life events compared to pregnant women without gestational diabetes.
- Women with gestational diabetes have higher perceived level of stress and anxiety compared to pregnant women without gestational diabetes.
- Women with gestational diabetes have higher measures of cortisol levels in the saliva and in the nailfolds and higher plasma copeptin levels compared to pregnant women without gestational diabetes.
1. To test the link between these stress measures and the fasting and stimulated glucose levels during the oral glucose tolerance test.
|Study Type :||Observational|
|Estimated Enrollment :||200 participants|
|Official Title:||Effects of Stress on Glucose Tolerance During Pregnancy|
|Study Start Date :||October 2012|
|Actual Primary Completion Date :||September 2013|
|Estimated Study Completion Date :||September 2017|
Women with gestational diabetes
Women with gestational diabetes diagnosed by clinically routine 75 g oral glucose tolerance testing
Women without gestational diabetes
Women without gestational diabetes diagnosed by clinically routine 75 g oral glucose tolerance testing
- Markers of stress [ Time Frame: At assessment ]stress (stressful life events, the perceived level of stress and the cortisol or copeptin concentrations)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01707784
|Maternité CHUV, University of Lausanne|
|Lausanne, Switzerland, 1011|
|Study Director:||Jardena J. Puder, MD||University of Lausanne|
|Principal Investigator:||Ji-Seon Kang||University of Lausanne|
|Principal Investigator:||Yvan Vial, MD||University of Lausanne|
|Principal Investigator:||Pr Ulrike Ehlert, PhD||University of Zurich|
|Principal Investigator:||Ayala Borghini, PhD||University of Lausanne|
|Principal Investigator:||Pedro Marques-Vidal, MD, PhD||University of Lausanne|