The Effects of Low- and High-intensity Resistance Exercise on Force-velocity Characteristics in Older Adults

This study has been completed.
Information provided by (Responsible Party):
Universitaire Ziekenhuizen Leuven Identifier:
First received: October 2, 2012
Last updated: February 19, 2013
Last verified: November 2011
The purpose of this study is to compare the impact of high- and low-intensity resistance exercise on force-velocity characteristics, muscle mass and inflammatory processes in older adults. As all training protocols are designed to end with maximal effort, effects are expected to be similar between groups.

Condition Intervention
Effects of Strength Training in Older Adults
Other: Strength training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Subject)

Further study details as provided by Universitaire Ziekenhuizen Leuven:

Primary Outcome Measures:
  • Change in force-velocity characteristics of knee extensors [ Time Frame: Baseline, 12weeks, 6 months ] [ Designated as safety issue: No ]

Other Outcome Measures:
  • Change in muscle volume [ Time Frame: Baseline, 12weeks, 6 months ] [ Designated as safety issue: No ]
  • Change in maximal strength (one repetition maximum) [ Time Frame: Baseline, 4weeks, 8weeks, 12weeks, 6 months ] [ Designated as safety issue: No ]
    Strength is measured as the maximum weight on the training equipment that can be lifted only one time (= one repetition maximum).

  • Change in motivation [ Time Frame: Baseline, every week for 12 weeks, 6 months ] [ Designated as safety issue: No ]
  • Change in physical activity [ Time Frame: Baseline, 12weeks, 6 months ] [ Designated as safety issue: No ]
  • Change in inflammatory markers in blood [ Time Frame: Baseline, 12weeks, 6 months ] [ Designated as safety issue: No ]

Enrollment: 56
Study Start Date: January 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: High-load strength training Other: Strength training
Active Comparator: Low-load strength training Other: Strength training
Active Comparator: Low-load + moderate-load strength training Other: Strength training


Ages Eligible for Study:   60 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • age 60 to 80 years

Exclusion Criteria:

  • Knee or hip prothesis
  • Systematic training
  • Cardiovascular disease
  • Acute lower back pain
  • Dementia
  Contacts and Locations
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Please refer to this study by its identifier: NCT01707017

Faculty of Kinesiology and Rehabilitation Sciences
Leuven, Belgium, 3001
Sponsors and Collaborators
Universitaire Ziekenhuizen Leuven
  More Information

Responsible Party: Universitaire Ziekenhuizen Leuven Identifier: NCT01707017     History of Changes
Other Study ID Numbers: S53709 
Study First Received: October 2, 2012
Last Updated: February 19, 2013
Health Authority: Belgium: Ethics Committee processed this record on May 26, 2016