Transient ECG Changes in Patients With Acute Biliary Disease
|ClinicalTrials.gov Identifier: NCT01706068|
Recruitment Status : Unknown
Verified October 2012 by Inna Rozenfeld , MD, Ziv Hospital.
Recruitment status was: Not yet recruiting
First Posted : October 15, 2012
Last Update Posted : October 15, 2012
The importance of ischemic ECG changes including St segment elevation, ST segment depression or T wave inversion that indicate myocardial ischemia are well established and require appropriate investigation and treatment.
However, there is an abundance of clinical situation, with apparently ischemic ECG change not indicate traditionally coronary artery related ischemia and therefore require prompt recognition and treatment of underlying condition, that may be serious and life-threatened. For example of such conditions are pericarditis, myocarditis, aortic dissection, electrolyte abnormalities, intracranial hemorrhage and hypothermia.
Together with them, an ECG ST segment changes may appeared in abdominal serious illness such as pancreatitis and cholecystitis(17,18,19,20,23). Whereas in pancreatitis various vasoactive and toxic for myocardium substances released, the cause of ST segment changes in cholecystitis are discussed and includes tachycardia , vagal reflexes, changed in plasma rennin activity resulted by distension of the gallbladder.
The certain proportion of the patients with ECG changes actually didn't have coronary artery disease(9,15) or other acute cardiac condition and therefore require treatment of the underlie illness only without spend the time for cardiac investigation or special treatment(1,3,4,7,8). Some kind of treatment may be even harmful for the patients with abdominal illness such as thrombolytic, anticoagulant, aggressive antiaggregant therapy or unnecessary cardiac catheterization.
In the medical literature the investigators found some case reports and works about the ECG changes in acute biliary disease in patient with knowing cardiac disease and without it, but actually incidence of ECG changes that suggest but not represent an acute coronary illness isn't knowing.
Therefore this is necessary to investigate actually incidence of ECG changes that mimic acute coronary syndrome in acute cholecystitis and acute biliary disease and determined clinical and laboratory characteristics that helps to differentiate this patients.
|Condition or disease|
|Acute Cholecystitis Biliary Colic Acute Cholangitis|
|Study Type :||Observational|
|Estimated Enrollment :||100 participants|
|Official Title:||Transient ECG Changes in Patients With Acute Biliary Disease|
|Study Start Date :||November 2012|
|Estimated Primary Completion Date :||November 2013|
|Estimated Study Completion Date :||May 2014|
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01706068
|Ziv Medical Center||Not yet recruiting|
|Zefat, Israel, 13100|
|Contact: Inna Rozenfeld, MD 972508434217 firstname.lastname@example.org|
|Principal Investigator: Inna Rozenfeld, MD|