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Effects of Legumes on Glucose Regulation

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ClinicalTrials.gov Identifier: NCT01706042
Recruitment Status : Completed
First Posted : October 15, 2012
Last Update Posted : October 15, 2012
Sponsor:
Collaborator:
Anti-Diabetic Food Centre
Information provided by (Responsible Party):
Anne Nilsson, Lund University

Brief Summary:
Dietary prevention strategies are increasingly recognized as essential to combat the current epidemic of obesity and related metabolic disorders. The purpose of the present study was to evaluate the potential effects of legumes in relation to cardiometabolic risk markers and appetite regulating hormones.

Condition or disease Intervention/treatment Phase
Dietary Prevention Other: legume meal Other: white bread Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 16 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Over-night Metabolic Effects of Legumes
Study Start Date : February 2010
Actual Primary Completion Date : August 2010
Actual Study Completion Date : August 2011

Arm Intervention/treatment
Placebo Comparator: white bread
White bread (based on 35 g available carbohydrates)
Other: white bread
Active Comparator: Legume meal
Legumes are consumed as a late evening meal(based on 35 g available carbohydrates)
Other: legume meal



Primary Outcome Measures :
  1. blood glucose [ Time Frame: 11 hours ]
    A portion of legumes or bread was consumed as a late evening meal, blood glucose was measured the next morning at breakfast.


Secondary Outcome Measures :
  1. satiety [ Time Frame: 11 hours ]
    legumes or bread was consumed as a late evening meal, satiety hormones (PYY, oxyntomodulin)and appetite sensations were determined at a following breakfast.


Other Outcome Measures:
  1. inflammatory markers [ Time Frame: 11 hours ]
    legumes or bread was consumed as a late evening meal, inflammatory markers (IL-6, IL-8)was determined at a following breakfast.



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Ages Eligible for Study:   20 Years to 35 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects between 20-35 years
  • With normal BMI and
  • No known metabolic- or gastro intestinal disease

Exclusion Criteria:

  • BMI > 25,
  • Known metabolic disorder or
  • Gastrointestinal problems or disease

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01706042


Locations
Sweden
Applied Nutrition and Food Chemistry, Lund University
Lund, Sweden, SE-22100
Sponsors and Collaborators
Lund University
Anti-Diabetic Food Centre