Effect of New Oral Anticoagulants Dabigatran and Rivaroxaban on Point of Care Coagulation Testing - an Ex-Vivo Study
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ClinicalTrials.gov Identifier: NCT01704053
Recruitment Status :
First Posted : October 11, 2012
Last Update Posted : August 15, 2014
Johann Wolfgang Goethe University Hospital
Information provided by (Responsible Party):
Dr. Matthias Klages, Johann Wolfgang Goethe University Hospital
The purpose of this study is determine whether point of care coagulation testing is able to map the anticoagulatory effects of new oral anticoagulants dabigatran and rivaroxaban. Used as devices are thrombelastometry/-graphy (ROTEM, TEG)and multiple platelet function analyzer (Multiplate).
Condition or disease
Clot Formation and Platelet Aggregation in Point of Care Testing
Patients receiving dabigatran or rivaroxaban in therapeutic doses are recruited. Blood will be taken twice in correlation to the time of drug intake (before and 3 hours after drug intake). The results of thrombelastometry/-graphy and multiple platelet function analyzer will be compared directly with the concentrations determined by plasma concentration assays.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Primary Care Clinic. Patients with non-valvular atrial fibrillation who receive Dabigatran or Rivaroxaban for prevention of stroke and systemic embolism.
Patients receiving Dabigatran or Rivaroxaban
Adults > 18 years
Patients receiving concomittantly inhibitors of platelet function