The Efficacy of Jobelyn (Sorghum Bicolor Extract)in the Treatment of Sickle Cell Anemia

This study has been completed.
Information provided by (Responsible Party):
Dr. A. O. Dosunmu, Lagos State University Identifier:
First received: October 3, 2012
Last updated: October 5, 2012
Last verified: October 2012
The primary objective is to determine if there is a significant increase in the haematocrit value of patients on Jobelyn and standard therapy compared to those on standard therapy alone.

Condition Intervention Phase
Sickle Cell Anemia
Drug: Paludrine + Folic Acid
Dietary Supplement: Paludrine + Folic Acid + Jobelyn
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Caregiver)
Primary Purpose: Treatment
Official Title: The Effect of Jobelyn ( Extract of Sorghum Bicolor) on the Haematological Parameters of Patients With Sickle Cell Anaemia Disease.

Resource links provided by NLM:

Further study details as provided by Lagos State University:

Primary Outcome Measures:
  • Number of Participants with Adverse Events [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
    The number of participants who reported with Adverse events for the 12-week duration of the study

Secondary Outcome Measures:
  • number of blood transfusions during the 12-week trial period [ Time Frame: 12 weeks ] [ Designated as safety issue: Yes ]
    No of blood transfusions carried out during the period as a result of anaemia

Enrollment: 150
Study Start Date: January 2012
Study Completion Date: August 2012
Primary Completion Date: March 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Paludrine + Folic Acid
This arm uses routine drugs, Paludrine + Folic Acid
Drug: Paludrine + Folic Acid
This is the combination of routine drugs for treating sickle cell disease
Other Name: Routine drugs
Active Comparator: Paludrine + Folic Acid + Jobelyn
This group uses Paludrine + Folic Acid + Jobelyn
Dietary Supplement: Paludrine + Folic Acid + Jobelyn
Combination of routine drugs + Jobelyn
Other Names:
  • 1. Routine Drugs, i.e. Paludirine + Folic Acid
  • 2. Sorghum bicolor extract (Jobelyn)

  Show Detailed Description


Ages Eligible for Study:   14 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Male or female 14 to 45 years of age
  • Haemoglobin SS

Exclusion Criteria:

  • Patients with chronic inflammatory disease like tuberculosis
  • Patients with chronic viral hepatitis or positive for human immunodeficiency virus
  • Patients with autoimmune disorders.

    . patients with other haemoglobinopathy

  • Pregnancy or anticipated pregnancy.
  • Patient on drug abuse or alcohol abuse.
  • Patients on treatment for organ failure
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01703104

Lagos State University Teaching Hospital
Ikeja, Lagos, Nigeria, 100001
Sponsors and Collaborators
Lagos State University
Principal Investigator: A O Dosunmu, M.D. Lagos State University
  More Information

Okochi,V.I.,Okpuzor J, Okubena M.O., Awoyemi A.K. 2003 . The Influence of African Herbal Formula on the haematological parameters of trypanosome infected rats. African Journal of Biotechnology. 2 (9), 312-316.
Erah P,O., Asonye C.C. Okhamafe A.O. 2003. Response of trypanosome brucei brucei induced anaemiato a commercialherbal preparation. African Journal of Biotechnology. 2,9, 307-311.
Ogwumike OO. Hemopoietic effect of aqueous extract of the leaf sheath of Sorghum bicolor in albino rats. African Journal of Biomedical. Research. (2002): Vol 5; 69 - 71
Akande IS, Oseni AA, Biobaku OA. Effects of aqueous extract of Sorghum bicolor on hepatic, histological and haematological indices in rats. Journal of Cell and Animal Biology 4(9), 137-142, 2010.
Nwinyi FC, Kwanashie HO. Evaluation of aqueous methanolic extract of Sorghum bicolor leaf base for antinociceptive and anti-inflammatory activities. African Journal of Biotechnology, 8 (18), 4642-4649, 2009.
Eniojukan JF, Bolajoko AA. Toxicological Profiles of Commercial Herbal Preperation, Jobelyn. International Journal of Health Research, 2(4), 369-374, 2009.
USDA Database for the Oxygen Radical Absorbance Capacity (ORAC) of Selected Foods, Release 2, U.S. Department of Agriculture, 2010.

Responsible Party: Dr. A. O. Dosunmu, CONSULTANT IN THE DEPARTMENT OF HAEMATOLOGY & BLOOD TRANSFUSION, LASUTH, Lagos State University Identifier: NCT01703104     History of Changes
Other Study ID Numbers: LASUTH/SCD02/2012
Study First Received: October 3, 2012
Last Updated: October 5, 2012
Health Authority: Nigeria: The National Agency for Food and Drug Administration and Control

Keywords provided by Lagos State University:
Sorghum bicolor
sickle cell anaemia
haematological parameters

Additional relevant MeSH terms:
Anemia, Sickle Cell
Anemia, Hemolytic
Anemia, Hemolytic, Congenital
Genetic Diseases, Inborn
Hematologic Diseases
Folic Acid
Vitamin B Complex
Anti-Infective Agents
Antiparasitic Agents
Antiprotozoal Agents
Growth Substances
Hematologic Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Therapeutic Uses
Vitamins processed this record on November 25, 2015