Neural Correlates of Empathogenic and Affiliative Actions of Oxytocin (ODIS)
Mounting evidence indicates that the intranasal administration of the neuropeptide oxytocin has prosocial effects. However, the neural substrates of these effects are still unclear. The investigators hypothesized that a single dose administration of oxytocin should increase empathogenic and affiliative responses and that these effects are mediated by an increased insula activity.
|Study Design:||Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Basic Science
|Official Title:||Neural Correlates of the Empathogenic and Affiliative Actions of Oxytocin|
- Empathy ratings and their neural correlates [ Time Frame: About one hour after the intranasal administration of oxytocin ] [ Designated as safety issue: No ]All subjects are scanned while they view emotional and neutral faces and rate their empathy for these stimuli.
- Neural correlates of pair-bonding [ Time Frame: About one hour after the intranasal administration of oxytocin ] [ Designated as safety issue: No ]All subjects are scanned while they view a picture of their mate and and an unknown female.
|Study Start Date:||August 2012|
|Study Completion Date:||August 2013|
|Primary Completion Date:||August 2013 (Final data collection date for primary outcome measure)|
24 IU Oxytocin, intranasal application 45 min prior to the experiment
24 IU; 3 puffs per nostril, each with 4 IU OXT
Other Name: Oxytocin: Syntocinon-Spray, Novartis
Placebo Comparator: Placebo
Intranasal application, sodium chloride solution, 3 puffs per nostril
Please refer to this study by its ClinicalTrials.gov identifier: NCT01701180
|Department of Psychiatry, University of Bonn|
|Bonn, North Rhine-Westphalia, Germany, 53105|
|Principal Investigator:||René Hurlemann, MD PhD M.Sc.||Department of Psychiatry University of Bonn|