Acid Production in Dental Plaque After Exposure to Probiotic Bacteria
![]() |
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. |
ClinicalTrials.gov Identifier: NCT01700712 |
Recruitment Status :
Completed
First Posted : October 4, 2012
Last Update Posted : October 4, 2012
|
- Study Details
- Tabular View
- No Results Posted
- Disclaimer
- How to Read a Study Record
The increasing interest in probiotic lactobacilli in health maintenance has raised the question of potential risks. One possible side effect could be an increased acidogenicity in dental plaque. The aim of this study was to investigate the effect of probiotic lactobacilli on plaque lactic acid (LA) production in vitro and in vivo.
Methods. subjects (n=18) were given lozenges with probiotic lactobacilli (L. reuteri DSM 17938 and ATCC PTA 5289) or placebo for two weeks in a double-blinded, randomized cross-over trial. The concentration of LA in supragingival plaque samples was determined at baseline and after 2 weeks. Salivary counts of mutans streptococci (MS) and lactobacilli were estimated with chair-side methods.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Caries | Dietary Supplement: Probiotic Lactobacilli reuteri Dietary Supplement: Placebo | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 18 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) |
Primary Purpose: | Prevention |
Study Start Date : | December 2010 |
Actual Primary Completion Date : | October 2011 |
Actual Study Completion Date : | October 2011 |
Arm | Intervention/treatment |
---|---|
Active Comparator: L. reuteri (DSM 17938 and ATCC PTA 5289; 1x108 CFU
2 tablets a day for 2 weeks
|
Dietary Supplement: Probiotic Lactobacilli reuteri |
Placebo Comparator: Sugar pill
2 tablets a day for 2 weeks
|
Dietary Supplement: Placebo |
- Acid production in plaque after exposure to probiotic bacteria [ Time Frame: 2 weeks ]
- Acid producton in plaque after in vitro exposure to probiotic bacteria [ Time Frame: 1 hour ]

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- moderate to high counts of salivary mutans streptococci (>104 CFU) as estimated with the Dentocult SM chair-side test,
- no visible open caries lesions or periodontal disease,
Exclusion Criteria:
- smokers,
- ingestion of probiotic bacteria within the last two months,
- ingestion of antibiotics within the last two months

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01700712
Denmark | |
University of Copenhagen | |
Copenhagen, Denmark, 2100 |
Principal Investigator: | Mette K Keller, PhD | University of Copenhagen |
Responsible Party: | Mette Kirstine Keller, Reasearch Associate, University of Copenhagen |
ClinicalTrials.gov Identifier: | NCT01700712 |
Other Study ID Numbers: |
H-2-2010-112 |
First Posted: | October 4, 2012 Key Record Dates |
Last Update Posted: | October 4, 2012 |
Last Verified: | October 2012 |
Caries, probiotic bacteria |