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Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)

This study has been completed.
Information provided by (Responsible Party):
Region Skane Identifier:
First received: September 25, 2012
Last updated: May 13, 2015
Last verified: May 2015

The purpose is to investigate how the adsorptive capacity of the active carbon filter to carbon dioxide in an anaesthetic gas reflector (AnaConDa) is affected by adding inhaled anaesthetic agent.

The hypothesis is that addition of inhaled anaesthetic agent will affect the amount of adsorption of carbon dioxide to the active carbon and thereby affect rebreathing of carbon dioxide.

Condition Intervention
Ischemic Heart Disease Other: Inhaled anaesthetic agent

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: Influence of Inhaled Anaesthetics on Rebreathing of Carbon Dioxide When Using an Anaesthesia Gas Reflector (AnaConDa)

Resource links provided by NLM:

Further study details as provided by Region Skane:

Primary Outcome Measures:
  • Volume of carbon dioxide rebreathing from an anesthetic gas reflector [ Time Frame: 2 hours ]
    Tidal carbon dioxide volume rebreathed from an anesthetic gas reflector correlated to concentration of delivered anesthetic gas.

Secondary Outcome Measures:
  • Quantification of ventilatory requirements to maintain isocapnia with the use of an anesthetic gas reflector. [ Time Frame: 2 hours ]
    Changes of tidal volume required to maintain constant alveolar ventilation will be assessed by continuous measurement of exhaled tidal carbon dioxide volume, the latter to be maintained at a constant value.

Enrollment: 12
Study Start Date: September 2012
Study Completion Date: December 2014
Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Inhaled anaesthetic agent
The group where the investigators adds inhaled anaesthetic agent when using the anaesthetic gas reflector (AnaConda).
Other: Inhaled anaesthetic agent


Ages Eligible for Study:   18 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • elective coronary artery by-pass graft surgery
  • elective valve replacement surgery
  • normal left ventricular ejection fraction on preoperative echocardiography

Exclusion Criteria:

  • obstructive lung disease
  • restrictive lung disease
  Contacts and Locations
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Please refer to this study by its identifier: NCT01699802

Skane University Hospital Lund, Cardiothoracic Intensive Care
Lund, Sweden, SE-221 85
Sponsors and Collaborators
Region Skane
Principal Investigator: Mikael Bodelsson, Professor Divison of Surgery, Department of Anaesthesia, Skane University Hospital, Lund, Sweden
  More Information

Responsible Party: Region Skane Identifier: NCT01699802     History of Changes
Other Study ID Numbers: 2012/148
Study First Received: September 25, 2012
Last Updated: May 13, 2015

Additional relevant MeSH terms:
Heart Diseases
Myocardial Ischemia
Coronary Artery Disease
Cardiovascular Diseases
Vascular Diseases
Coronary Disease
Arterial Occlusive Diseases
Central Nervous System Depressants
Physiological Effects of Drugs processed this record on September 20, 2017